Identification of Prodromal Neurodegeneration in Serotonergic-Induced REM Sleep Behavior Disorder
Recruiting
N/A
Interventional Study
Dementia With Lewy Bodies
Parkinson Disease
REM Sleep Behavior Disorder
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
At a Glance
- Age
- 18 – 75
- Sex
- Any
- Study type
- Interventional
- Purpose
- Basic Science
- Participants needed
- 60 (estimated)
- Sponsor
- University of Minnesota · Other
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About This Trial
This project will test the hypotheses that people with 5-HT RBD have systemic alpha- synuclein pathology, prodromal DLB signs, and brainstem lesions in regions that control REM sleep. AIM 1 will seek to detect abnormally phosphorylated alpha- synuclein aggregates on targeted skin biopsy in a cohort of people with 5-HT RBD and matched controls (taking SSRIs but without RBD). Aim 2 will use ultra-hi…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
Serotonergic REM sleep behavior (5-HT RBD) participants
Inclusion Criteria:
* Diagnosis of polysomnogram-confirmed RBD with history of dream enactment or clear dream enactment visualized on video from polysomnogram.
* History of dream enactment began shortly after (less than 2…
Contacts