TEV-56278 for Advanced Solid Tumors

An Open-label Dose Escalation/Expansion Trial to Evaluate the Safety and Anti-tumor Activity of TEV-56278 Alone or in Combination With Pembrolizumab in Participants With Advanced or Metastatic Solid Tumors

Recruiting Phase 1 Interventional Study
Advanced Solid Tumors
No Placebo Group Every participant receives an active treatment — no one gets a placebo.
Ready to participate?

Review the details below, then apply to join this clinical trial.

At a Glance
Age
18 and older
Sex
Any
Trial phase
Phase 1
Study type
Interventional
Purpose
Treatment
Participants needed
240 (estimated)
Sponsor
Teva Branded Pharmaceutical Products R&D LLC · Industry
Who this trial is looking for

This trial is looking for people with advanced solid tumors who have not responded to standard treatments or cannot receive them. Participants will receive a treatment for up to 12 months, with follow-up for an additional 12 months.

Are You a Good Fit for This Trial?

You may be able to join if

  • I have been diagnosed with an advanced solid tumor.
  • I have received standard treatments but my condition has progressed.
  • I have a life expectancy of at least 12 weeks.
  • I agree to use effective birth control during the trial.
  • I am male and will use condoms and avoid donating sperm during the trial.

You may not be able to join if

  • I have had cancer treatment within the last 4 weeks.
  • I have received certain types of growth factors or transfusions recently.
  • I have a known immunodeficiency.
  • I have active autoimmune disease.
  • I have a history of brain metastases or meningitis.
  • I have had a serious infection needing treatment within the last 14 days.
  • I have experienced significant heart or brain issues in the last 6 months.
  • I have interstitial lung disease or active lung inflammation.

Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.

Think this trial could be right for you?

Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.

Check Your Eligibility
About This Trial
The primary objectives of this trial are to: * Characterize the safety and tolerability of TEV-56278 * Determine the Recommended Phase 2 Dose (RP2D) * Evaluate antitumor activity of TEV-56278 (Part 2 only) * Determine the safety and tolerability of TEV-56278 in combination with pembrolizumab * Determine a RP2D of TEV-56278 in combination with pembrolizumab The secondary objectives of this trial …
Trial Locations
Loading…

Loading trial locations…

Eligibility Criteria
Inclusion Criteria: * Have an established histological diagnosis of selected solid tumor and must have received and progressed on established standard therapies or have been intolerant to such therapy or have been considered by the Investigator as ineligible for approved standard therapy * Have a l…
Contacts

Teva U.S. Medical Information

1-888-483-8279

USMedInfo@tevapharm.com

CONTACT