No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Prior Safety Data
This treatment has already been tested in at least one earlier human trial.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
50 and older
Sex
Any
Trial phase
Phase 2
Study type
Interventional
Purpose
Treatment
Participants needed
50 (estimated)
Sponsor
EyebioKorea, Inc. · Industry
Who this trial is looking for
This trial is looking for adults aged 50 and older with a specific eye condition called neovascular age-related macular degeneration (nAMD). Participants will take a treatment called EB-203 to help understand its safety and effects on vision.
Are You a Good Fit for This Trial?
Rules you outScarring of the foveaChoroidal neovascularization from causes other than nAMD
You may be able to join if
I am 50 years old or older.
My best corrected vision score is between 25 and 73.
I have signed the consent form to join the study.
You may not be able to join if
I require standard treatment for nAMD in both eyes.
I have received treatments like laser therapy or surgery for nAMD.
I have been treated with anti-VEGF drugs before the study.
I have had steroid injections in my eye.
I have bleeding in the eye area that is too extensive.
I have a vitreous hemorrhage in my study eye.
I have had vitrectomy surgery.
I have a history of retinal detachment.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer a few quick questions to see if you may meet the eligibility requirements.
Trial to Evaluate the Safety and Efficacy of EB-203 in Patients with Neovascular Age-related Macular Degeneration.
The purpose of this study is to primarily investigate the safety and tolerability of EB-203 by dose in patients with neovascular Age-related Macular Degeneration (nAMD), and to secondarily evaluate the clinical efficacy. Subject to Adults aged 50 years or older and Neovascular age-re…
Trial to Evaluate the Safety and Efficacy of EB-203 in Patients with Neovascular Age-related Macular Degeneration.
The purpose of this study is to primarily investigate the safety and tolerability of EB-203 by dose in patients with neovascular Age-related Macular Degeneration (nAMD), and to secondarily evaluate the clinical efficacy. Subject to Adults aged 50 years or older and Neovascular age-related macular degeneration (nAMD)
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
1. Adults aged 50 years or older
2. Subjects with a best corrected visual acuity (BCVA) score between 25 and 73, measured by the Early Treatment of Diabetic Retinopathy Study(ETDRS) chart, at a distance of 4 m during the screening (equivalent to 20/40 to 20/320 in the Snellen ch…
Inclusion Criteria:
1. Adults aged 50 years or older
2. Subjects with a best corrected visual acuity (BCVA) score between 25 and 73, measured by the Early Treatment of Diabetic Retinopathy Study(ETDRS) chart, at a distance of 4 m during the screening (equivalent to 20/40 to 20/320 in the Snellen chart)
3. Subjects who voluntarily signed the informed consent form (ICF) after receiving the information on this study
Exclusion Criteria:
1. Subjects with confirmed nAMD requiring standard treatment in both eyes (however, dry AMD in the non-study eye may be enrolled)
2. Subjects who have received ocular or systemic treatment, such as photodynamic therapy (PDT) or laser photocoagulation, or have undergone a surgical operation for nAMD (however, health functional foods, vitamin supplements, etc., are excluded)
3. Subjects whose study eye has been treated with anti-vascular endothelial growth factor (anti-VEGF) drugs (e.g. ranibizumab, bevacizumab, aflibercept, etc.) or a combination therapy for the treatment of nAMD prior to screening
4. Subjects who have received intravitreal treatment using steroids
5. Subjects who have a subretinal hemorrhage in ≥ 50% of the total lesion area or who have a hemorrhage in the subfoveal region of the study eye and in whom the hemorrhage area is ≥ 1 optic disk area
6. Subjects with vitreous hemorrhage in the study eye
7. Subjects who have undergone vitrectomy
8. Subjects with a history of retinal detachment, congenital disease, or treatment and/or surgical history for retinal detachment
9. Subjects with scarring, fibrosis, or atrophy involving the center of the fovea of the study eye
10. Subjects with choroidal neovascularization in the study eye due to causes other than nAMD (however, polypoidal choroidal vasculopathy (PCV) can be enrolled)
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