New MRI Techniques for Optic Neuritis in Multiple Sclerosis
Comparison of Diagnostic Performances of 3D FLAIR, DIR and PSIR Sequences in Optic Neuritis
Recruiting
Observational Study
Multiple SclerosisDemyelinating Diseases
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
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At a Glance
Age
18 and older
Sex
Any
Study type
Observational
Participants needed
60 (estimated)
Sponsor
University Hospital, Strasbourg, France · Other
Who this trial is looking for
This trial is looking for adults with multiple sclerosis or NMO spectrum diseases. Participants will undergo MRI scans using different techniques to help improve the detection of optic neuritis.
Are You a Good Fit for This Trial?
You may be able to join if
I am at least 18 years old
I have been diagnosed with multiple sclerosis or an NMO spectrum disease
I have had an MRI that included 3D FLAIR, 3D DIR, and 3D PSIR sequences
My brain MRI was done between April 1, 2019 and November 30, 2021
I agree to allow my data to be used for scientific research
You may not be able to join if
I do not agree to allow my data to be used for scientific research
My MRI had artifacts that make results hard to interpret
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
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Ultimately improve the care of patients suffering from multiple sclerosis (1st cause of acquired non-traumatic disability in adults) and NMO spectrum diseases by using more efficient MRI sequences than the FLAIR sequence commonly used in detection of optic neuritis.
In the literature, many studies have already focused on comparing the sensitivity of detection of white matter demyelination plaques…
Ultimately improve the care of patients suffering from multiple sclerosis (1st cause of acquired non-traumatic disability in adults) and NMO spectrum diseases by using more efficient MRI sequences than the FLAIR sequence commonly used in detection of optic neuritis.
In the literature, many studies have already focused on comparing the sensitivity of detection of white matter demyelination plaques using FLAIR, PSIR or DIR sequences.
Some authors have shown better sensitivity of the PSIR sequence in the detection of demyelinating lesions of the marrow in multiple sclerosis compared to conventional sequences.
Others have shown better performance of the combined use of PSIR and DIR sequences compared to the FLAIR sequence in the detection of cortical lesions in multiple sclerosis.
However, in the context of optic neuritis, few comparative studies comparing these three sequences have been carried out:
A 2022 study showed better diagnostic sensitivity of optic neuritis of the DIR sequence compared to the FLAIR sequence.
A possible better diagnostic performance of a sequence not used in current practice in the detection of optic neuritis (PSIR and DIR sequences), would be possible to justify their use on a larger scale and ultimately improve patient care.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Major subject (≥18 years old)
* Subject suffering from multiple sclerosis or an NMO spectrum disease
* Subject having received an MRI including 3D FLAIR, 3D DIR and 3D PSIR sequences
* Brain MRIs of eligible subjects acquired between April 1, 2019 and November 30, 2021.
* No o…
Inclusion Criteria:
* Major subject (≥18 years old)
* Subject suffering from multiple sclerosis or an NMO spectrum disease
* Subject having received an MRI including 3D FLAIR, 3D DIR and 3D PSIR sequences
* Brain MRIs of eligible subjects acquired between April 1, 2019 and November 30, 2021.
* No opposition to the reuse of its data for scientific research purposes.
Exclusion Criteria:
* Presence of opposition from the subject (and/or their legal representative if applicable) to the reuse of their data for scientific research purposes.
* Artifacts not allowing satisfactory interpretation
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