Effect of Genicular Arteries Embolization in Symptomatic Knee Osteoarthritis LipioJoint-2

Inclusion Criteria: * Diagnosis of primary KOA according to the classification of the American College of Rheumatology (ACR) (5) * Radiographic Kellgren and Lawrence score ≥ 2 (6) * VAS pain score ≥ 40 mm (scale 0-100 mm) * Previous intra-articular injection in the target knee * Patient not eligible to knee surgery * For woman of childbearing potential: negative bêta-HCG before randomization * Social security affiliation * Signed informed consent * Good understanding of the French language Exclusion Criteria: * Intra-articular injection of any product in the target joint within 3 months before embolization * Prior knee surgery other than ligament repair * Any inflammatory joint disease other than osteoarthritis * Any contra-indication to puncture of the ipsilateral femoral artery * Current treatment with cyclosporine, tacrolimus, cisplatine, vancomycine, amphotericine B or any aminoside * Ipsilateral symptomatic hip OA * Treated hyperthyroidism * Known severe allergy to Lipiodol® and/or iodine contrast medium * Known moderate to severe kidney failure (creatinine clearance \< 30 45 ml/min) * Known right-to-left cardiac shunt or intra-tumoral vascular shunt * Asthma attack in the 8 days before randomization * Exploration or treatment with radioactive iodine scheduled within 1 month after randomization * Symptomatic atheromatous lesion in the ipsilateral limb * Patient unable or unwilling to comply with the follow-up schedule (at the investigator's discretion) * Vulnerable populations (such as pregnant or breastfeeding women, patient under guardianship curatorship, deprived of liberty) * Patient under exclusion period in another trial * Patient on AME (state medical aid)