Intravenous Vesicular Stomatitis Virus in Patients With Peripheral T-cell Lymphoma

Recruiting Phase 1 Interventional Study
Peripheral T Cell Lymphoma Relapsed Peripheral T-Cell Lymphoma Peripheral T-Cell Lymphoma, Not Otherwise Specified Anaplastic Large Cell Lymphoma Mycosis Fungoides Relapsed Anaplastic Large Cell Lymphoma Relapsed Mycosis Fungoides
No Placebo Group Every participant receives an active treatment — no one gets a placebo.
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At a Glance
Age
18 and older
Sex
Any
Trial phase
Phase 1
Study type
Interventional
Purpose
Treatment
Participants needed
21 (estimated)
Sponsor
Mayo Clinic · Other
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About This Trial
This phase I trial studies the best dose and side effects of recombinant vesicular stomatitis virus (VSV) carrying the human (h) sodium iodide symporter (NIS) and Interferon (IFN) beta (β) genes (VSV-hIFNβ-NIS) in combination with cemiplimab in patients with T-cell lymphoma. A virus, called VSV-hIFNβ-NIS, which has been changed in a certain way, may be able to kill cancer cells without damaging no…
Trial Locations
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Eligibility Criteria
Inclusion Criteria: * Age \>= 18 years * Relapsed or refractory: * Group E only: Relapsed peripheral T-cell lymphoma (PTCL) of the following histologies: peripheral T-cell lymphoma-NOS (PTCL-NOS); anaplastic large cell (ALCL), and mycosis fungoides (MF) * Alanine aminotransferase (ALT) and aspar…
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