Intravenous Vesicular Stomatitis Virus in Patients With Peripheral T-cell Lymphoma
Recruiting
Phase 1
Interventional Study
Peripheral T Cell Lymphoma
Relapsed Peripheral T-Cell Lymphoma
Peripheral T-Cell Lymphoma, Not Otherwise Specified
Anaplastic Large Cell Lymphoma
Mycosis Fungoides
Relapsed Anaplastic Large Cell Lymphoma
Relapsed Mycosis Fungoides
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
At a Glance
- Age
- 18 and older
- Sex
- Any
- Trial phase
- Phase 1
- Study type
- Interventional
- Purpose
- Treatment
- Participants needed
- 21 (estimated)
- Sponsor
- Mayo Clinic · Other
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About This Trial
This phase I trial studies the best dose and side effects of recombinant vesicular stomatitis virus (VSV) carrying the human (h) sodium iodide symporter (NIS) and Interferon (IFN) beta (β) genes (VSV-hIFNβ-NIS) in combination with cemiplimab in patients with T-cell lymphoma. A virus, called VSV-hIFNβ-NIS, which has been changed in a certain way, may be able to kill cancer cells without damaging no…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Age \>= 18 years
* Relapsed or refractory:
* Group E only: Relapsed peripheral T-cell lymphoma (PTCL) of the following histologies: peripheral T-cell lymphoma-NOS (PTCL-NOS); anaplastic large cell (ALCL), and mycosis fungoides (MF)
* Alanine aminotransferase (ALT) and aspar…
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