A Study on the Efficacy of Androgen Deprivation Therapy Combined With Anti-PD-1 Therapy in Advanced Lung Cancer

Recruiting N/A Interventional Study
NSCLC, Stage III NSCLC, Stage IV
No Placebo Group Every participant receives an active treatment — no one gets a placebo.
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At a Glance
Age
60 and older
Sex
Male
Study type
Interventional
Purpose
Treatment
Participants needed
80 (estimated)
Sponsor
Jinzhou Medical University · Other
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About This Trial
Androgen Deprivation Therapy (ADT) triggers thymic revitalization and increases thymic output, enhancing baseline anti-tumor immunity and responses to immunotherapies. Anti-tumor synergism has been identified by combining ADT with anti-PD-1 immunotherapy for androgen-independent tumors. This study is to investigate the combination of Leuprorelin ADT and Sintilimab (anti-PD-1) therapy in patients w…
Trial Locations
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Eligibility Criteria
3.Inclusion Criteria: 1. Male patients aged ≥60 years. 2. ECOG performance status score of 0 \~1. 3. Expected survival time of more than 3 months. 4. Histologically or cytologically diagnosed advanced lung cancer according to the TNM staging system established by AJCC. 5. Patients who have not prev…
Contacts

Wangzhi Wei

(86)13941620158

weiwangzhi@jzmu.edu.cn

CONTACT

Shuangning Yang

(86)15138955506

CONTACT