The aim of this study was to compare the efficacy and safety of adrenalectomy and superselective adrenal artery embolization in a prospective, multicenter, randomized controlled study. To provide a new interventional alternative therapy for primary aldosteronism.
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Eligibility Criteria
Inclusion Criteria:
* Age 18-60
* Diagnosed with primary aldosteronism according to the 2016 Clinical guidelines of the International Endocrine Society
* Primary aldosteronism diagnosed according to international guidelines Unilateral disease by AVS or PET-CT criteria
* Patients and their family me…
Inclusion Criteria:
* Age 18-60
* Diagnosed with primary aldosteronism according to the 2016 Clinical guidelines of the International Endocrine Society
* Primary aldosteronism diagnosed according to international guidelines Unilateral disease by AVS or PET-CT criteria
* Patients and their family members signed informed consent and agreed to participate in the study
Exclusion Criteria:
* A history of severe hypersensitivity to contrast media
* Severe liver disease complications, such as thrombocytopenia, esophageal varices rupture bleeding, etc
* Renal insufficiency (serum creatinine \> 176mmol/L or estimated glomerular filtration rate \< min.1.73m2)
* Combined with other secondary hypertension, such as pheochromocytoma, hypercortisolism, renal vascular hypertension (such as renal artery stenosis), renin secretory tumor, renal parenchymatous hypertension, drug-induced hypertension (such as long-term use of glucocorticoids, contraceptives, estrogen, herbal medicines containing glycyrrhizin), pregnancy hypertension and other secondary hypertension
* Combined with genetic diseases: such as false aldosteronism (Liddle syndrome), Bartter syndrome, familial hypokalemia and hypomagnesia (Gitelman syndrome)
* Stroke, myocardial infarction and stent implantation occurred in the past 3 months
* Serious other diseases, such as heart dysfunction (grade IV), acute infections, autoimmune diseases, various malignant tumors, etc
* Participated in other clinical trials within the past 3 months
* Pregnant, breastfeeding, or planning a pregnancy
* Identify patients with alcohol allergy
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