Beta-blOckers discoNtinuation in Patients Presenting Heart FaIlure With REcovered Left Ventricular Ejection Fraction

Recruiting Phase 3 Interventional Study
Heart Failure
No Placebo Group Every participant receives an active treatment — no one gets a placebo. Pivotal Trial This treatment is in the last trial phase before FDA approval. Prior Safety Data This treatment has already been tested in at least one earlier human trial.
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At a Glance
Age
18 and older
Sex
Any
Trial phase
Phase 3
Study type
Interventional
Purpose
Other
Participants needed
1,300 (estimated)
Sponsor
Assistance Publique - Hôpitaux de Paris · Other
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About This Trial
A significant proportion of patients initially diagnosed with heart failure and a reduced left ventricular ejection fraction (LVEF\<40%, HFrEF) presents a substantial improvement in response to evidence-based medical and device therapies. Some of these patients (estimated from 20 to 30%) even display a complete normalization of LVEF (i.e., \>50%) and are now recognized as a specific sub-group of p…
Trial Locations
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Eligibility Criteria
Inclusion Criteria: 1. Age ≥ 18 years-old 2. Established diagnosis of HF for more than 12 months, from an ischemic or a non-ischemic origin 3. With a documented history of reduced left ventricular ejection fraction (LVEF ≤ 45%), followed by a normalisation of LVEF (≥ 50 % for the last 6 months) ass…
Contacts

Jean Sébastien HULOT, MD, PhD

01 56 09 20 17

jean-sebastien.hulot@aphp.fr

CONTACT