Clinical Characteristics and Prognosis of Acute Stroke in Pregnancy and Puerperium

1\. Case-control Study and Cohort Study on Recurrent Stroke Risk: Inclusion Criteria: 1. Female patients ≥18 years of age; 2. Patients or their legally acceptable representatives or relatives agree to collect personal information for this study and sign an oral or online written informed consent. Exclusion Criteria: 1. Patients or their legally acceptable representatives or relatives refuse follow-up; 2. Patients missing critical baseline demographic, clinical or neuroimaging data. 2\. Cohort Study on Offspring Outcomes: Inclusion Criteria: 1. Female patients ≥18 years of age; 2. Patients in pregnancy or within 6 weeks postpartum; 3. Patients or their legally acceptable representatives or relatives agree to collect personal information for this study and sign an oral or online written informed consent. Exclusion Criteria: 1. Patients or their legally acceptable representatives or relatives refuse follow-up; 2. Patients missing critical baseline demographic, clinical or neuroimaging data; 3. Patients whose offsprings have congenital malformation or inborn error of metabolism; 4. Patients with complications which may affect cerebral blood flow supply, such as amniotic fluid embolism, in pregnancy; 5. Patients whose family members other than the parents and siblings of their offsprings have a history of severe mental illness, such as mental retardation, autism and schizophrenia; 6. Patients undergo acute myocardial infarction in pregnancy; 7. Patients undergo non-spontaneous stroke events due to other causes, such as cerebral infarction or hemorrhage caused by surgery.