Mechanisms of Improving Fecal Continence Muscles Motor Function
Recruiting
N/AInterventional Study
Fecal Incontinence
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
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Review the details below, then apply to join this clinical trial.
At a Glance
Age
18 and older
Sex
Any
Study type
Interventional
Purpose
Basic Science
Participants needed
340 (estimated)
Sponsor
Medical College of Wisconsin · Other
Who this trial is looking for
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The investigators hypothesize that different continence muscles have different fatigue characteristics and fatigue induced by resisted contractions will result in significant increase in contractility of the continence muscles and improvement of fecal incontinence severity.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Healthy volunteers without past or present history of fecal incontinence
* Patients age 18 years and older with reduced anal resting and or squeeze pressure, reflecting weakness of the anal sphincters who can perform the study
Exclusion Criteria:
* Any one less than 18 years…
Inclusion Criteria:
* Healthy volunteers without past or present history of fecal incontinence
* Patients age 18 years and older with reduced anal resting and or squeeze pressure, reflecting weakness of the anal sphincters who can perform the study
Exclusion Criteria:
* Any one less than 18 years old
* Neurological disorders like dementia, cerebrovascular diseases
* Muscle diseases like muscular dystrophy, myopathies
* Inflammatory bowel disease or celiac disease
* Neuro-muscular junction disorders/myasthenia gravis, Eaton-Lambert syndrome
* Organ prolapse, large rectocele(\>2cm), rectal intussusception
* Hip dysplasia or recent hip surgery and immobile patients.
* Patients with complete normal anal resting and squeeze pressure
* Impaired rectal evacuation (dyssynergy defecation)
* Fecal incontinence completely due to loss of rectal sensation
* Subjects unable to contract their external anal sphincter at all
Contacts
No contact information available.
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