Telephone Support in Advanced Gastrointestinal Cancer

Patient Inclusion Criteria: * Patient is at least 3 weeks post-diagnosis of unresectable stage III or stage IV gastrointestinal cancer (i.e., ampullary, anal, appendix, bile duct, colon, esophageal, gallbladder, liver, pancreatic, rectal, small intestine, or stomach cancer) and is receiving cancer care at one of the study sites. * Patient is at least 18 years of age. * Patient can speak and read English. * Patient has an eligible, consenting family caregiver (see criteria below). * Patient has moderate to severe fatigue interference with functioning. Patient Exclusion Criteria: * Patient shows significant psychiatric or cognitive impairment that would preclude providing informed consent and study participation. * Patient reports being able to do little activity on a functional status measure. * Patient is receiving hospice care at screening. * Patient does not have working phone service. * Patient has hearing impairment that precludes participation. * Patient participated in the pilot trial testing the same intervention. Caregiver Inclusion Criteria: * Family caregiver identified by a gastrointestinal cancer patient who meets the eligibility criteria. * Caregiver has significant caregiving burden. * Caregiver lives with the patient or has visited the patient in-person at least twice a week for the past month. * Caregiver is at least 18 years of age. * Caregiver can speak and read English. Caregiver Exclusion Criteria: * Caregiver shows significant psychiatric or cognitive impairment that would preclude providing informed consent and study participation. * Caregiver does not have working phone service. * Caregiver has hearing impairment that precludes participation. * Patient declines study participation.