Observation of Clinical Consistency of Organoid-chips Drug Sensitivity in Chemotherapy for PCa With Visceral Metastasis

Inclusion Criteria: 1. Patients with visceral metastasis of prostate cancer diagnosed clinically or pathologically; 2. Age ≥ 18 years old; 3. ECOG score ≤ 2 points or ECOG score 3-4 points due to tumor progression; 4. Normal liver and kidney function, serum transaminase ALT\<66 U/L, AST\<36 U/L, total bilirubin\<22 umol/L, creatinine\<106 umol/L, urea nitrogen\<6.1 mmol/L; Normal bone marrow function: neutrophil count ≥ 1800/mm3 and platelet count ≥ 100000/mm3; 5. Can obtain surgical or biopsy samples; 6. Patients voluntarily join this study and sign an informed consent form. Exclusion Criteria: 1. Patients with severe heart, liver, kidney, and peripheral nervous system diseases, as well as autoimmune diseases such as hyperthyroidism and hypothyroidism; Systemic lupus erythematosus, etc; 2. Patients who are unable to obtain tissue samples; 3. Subjects with active pulmonary tuberculosis (TB); 4. Subjects who are preparing for or have previously undergone tissue/organ transplantation; 5. Exclusion criteria are not listed, but the researchers believe that patients who are not suitable to participate in this clinical study.