Luminal Fructose Kinetics (MARTINI Study)
Recruiting
Phase 2
Interventional Study
MASLD
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Prior Safety Data
This treatment has already been tested in at least one earlier human trial.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
At a Glance
- Age
- 18 – 65
- Sex
- Any
- Trial phase
- Phase 2
- Study type
- Interventional
- Purpose
- Basic Science
- Participants needed
- 22 (estimated)
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · Other
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About This Trial
In this study the investigators aim is to explore the dynamics of (small) intestinal fructose catabolism in humans and ethanol production in relation to small intestinal signalling pathways and changes in pH, using 13C fructose isotope tracing techniques complemented with direct luminal sampling via small intestinal catheter in biopsy proven MASLD/MASH patients vs healthy (BMI\<25) subjects. Addit…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
In case of the healthy subject group:
* Adult individuals, age \> 18 \<65 years
* Male or postmenopauzal females
* BMI \<25
* Ability to give informed consent In case of the MASLD/MASH group
* Adult individuals, age \> 18 \<65 years
* Male or postmenopauzal females
* BMI \> 25
…
Contacts