The Effect of Melatonin Supplementation on Cumulus Cells and IVF Outcomes
Recruiting
N/A
Interventional Study
Unrecognized Condition
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
At a Glance
- Age
- 35 – 45
- Sex
- Female
- Study type
- Interventional
- Purpose
- Treatment
- Participants needed
- 200 (estimated)
- Sponsor
- Kaohsiung Veterans General Hospital. · Other
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About This Trial
This study investigates the effects of melatonin supplementation on cumulus cell gene expression and in vitro fertilization (IVF) outcomes in women over 35 years old. In the study group, patients will receive melatonin supplementation for at least two months prior to their IVF cycles. Cumulus cells will be collected after oocyte retrieval, and IVF outcomes will be assessed.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Age 35-45 years
* BMI 18-30 kg/m2
* planning to undergo IVF cycles
Exclusion Criteria:
* Primary ovarian insufficiency
* history of oophorectomy
* receiving oocyte donation
* Chromosome anomaly
* Congenital uterine anomaly
* Severe intrauterine adhesion
* Malignancy
* Using …