No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
60 and older
Sex
Any
Study type
Observational
Participants needed
1,800 (estimated)
Sponsor
Washington University School of Medicine · Other
Who this trial is looking for
This trial is looking for older adults to help understand blood markers related to Alzheimer's disease. Participants will provide blood samples and medical information to help researchers learn how to diagnose and predict Alzheimer's using blood tests.
Are You a Good Fit for This Trial?
You may be able to join if
I am at least 60 years old
I have symptoms of forgetfulness or mild cognitive issues
I am invited to participate as part of the SEABIRD group
You may not be able to join if
I cannot perform basic daily activities due to cognitive issues
I have uncontrolled hepatitis B, hepatitis C, or HIV
I am taking a disease-modifying drug for Alzheimer's disease
I have had a blood transfusion in the last three months
I am unwilling or unable to participate in all study activities
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
The purpose of this study is to determine the relationships between amyloid, tau, and neurodegeneration biomarkers in the blood and the presence of Alzheimer's disease (AD) pathology, clinical cognitive decline, and diagnosis. We aim to understand how well blood-based biomarkers can diagnose and predict Alzheimer's disease, which will help to further develop and validate blood tests for the diseas…
The purpose of this study is to determine the relationships between amyloid, tau, and neurodegeneration biomarkers in the blood and the presence of Alzheimer's disease (AD) pathology, clinical cognitive decline, and diagnosis. We aim to understand how well blood-based biomarkers can diagnose and predict Alzheimer's disease, which will help to further develop and validate blood tests for the disease.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* At least 60 years of age
* 80% of the newly enrolled clinic-based cohort will have symptoms of forgetfulness, mild cognitive impairment, mild dementia, or Alzheimer's disease as determined by their medical chart and/or provider
* All SEABIRD participants will be invited to par…
Inclusion Criteria:
* At least 60 years of age
* 80% of the newly enrolled clinic-based cohort will have symptoms of forgetfulness, mild cognitive impairment, mild dementia, or Alzheimer's disease as determined by their medical chart and/or provider
* All SEABIRD participants will be invited to participate regardless of their cognitive status
Exclusion Criteria:
* Unable to perform one or more basic activities of daily living (eating, bathing, dressing, ambulating, toileting) due to cognitive impairment
* Uncontrolled hepatitis B, hepatitis C, or HIV at time of blood collection
* Taking a disease-modifying drug for AD at time of enrollment
* Blood transfusion in the last three months
* Unwilling or unable to participate in all study activities
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