Small Nerve Fiber Activity in Patients with Carpal Tunnel Syndrome Assessed Via Quantitative Sensory Testing
Recruiting
N/AInterventional Study
Carpal Tunnel Syndrome
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
18 – 65
Sex
Any
Study type
Interventional
Purpose
Treatment
Participants needed
48 (estimated)
Sponsor
Brooke Army Medical Center · Federal
Who this trial is looking for
This trial is looking for adults with carpal tunnel syndrome to participate in physical therapy. Researchers want to see how physical therapy affects nerve activity and patient outcomes.
Are You a Good Fit for This Trial?
You may be able to join if
I am aged 18-65
I have pain and tingling in my hand
I have a positive Phalen test
I have a positive Tinel test over the carpal tunnel
I am willing to attend physical therapy
You may not be able to join if
I have nerve root signs that suggest radiculopathy
I have suspected issues with my radial or ulnar nerves
I have had hand surgery before
I have had injections in my upper body in the last 6 months
I have had trauma to my neck, shoulder, or arm in the last 6 months
I am currently pregnant or have just given birth in the last 6 months
I have only received minimal care for my current condition
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
The diagnosis of carpal tunnel syndrome (CTS) is typically based on clinical findings and confirmatory electrodiagnostic testing. However, electrodiagnostic testing can only assess large A-alpha and A-beta nerve fibers. Quantitative sensory testing (QST) is a series of tests used to assess small nerve fiber changes in the A-delta, c-fibers, and A-beta nerve fibers as well. Previous studies have us…
The diagnosis of carpal tunnel syndrome (CTS) is typically based on clinical findings and confirmatory electrodiagnostic testing. However, electrodiagnostic testing can only assess large A-alpha and A-beta nerve fibers. Quantitative sensory testing (QST) is a series of tests used to assess small nerve fiber changes in the A-delta, c-fibers, and A-beta nerve fibers as well. Previous studies have used QST to assess small nerve fiber changes related to carpal tunnel syndrome and found changes compared to controls. This study will utilize a course of standard physical therapy care and assess for any changes to small nerve fiber activity and how those changes may or may not relate to patient outcomes.
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Eligibility Criteria
Inclusion Criteria:
DEERS eligible Age 18-65 Pain and paresthesia in the median nerve distribution A positive Phalen test A positive Tinel test over the carpal tunnel Willing to attend physical therapy
Exclusion Criteria:
Nerve root signs consistent with a radiculopathy Suspected radial and ulnar…
Inclusion Criteria:
DEERS eligible Age 18-65 Pain and paresthesia in the median nerve distribution A positive Phalen test A positive Tinel test over the carpal tunnel Willing to attend physical therapy
Exclusion Criteria:
Nerve root signs consistent with a radiculopathy Suspected radial and ulnar nerve involvement based on monofilament testing Bilateral CTS Previous hand surgery Injections in the upper quarter in the last 6 months Cervical, shoulder, or UE trauma in the last 6 months Currently pregnant or postpartum within the last 6 months No more than minimal care (evaluation and patient education, 1 visit) for the current episode
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