Metabolism-Informed Care to Aid Alaska Native People to Quit Smoking (QUIT)

Inclusion Criteria: (Patients) * Alaska Native or American Indian person by self-report * eligible for or already receiving services at Southcentral Foundation (SCF) * age 18 years or older * daily smoking in the past 30-days * if other nicotine or tobacco products are used, cigarettes are main product used * planning to schedule an appointment with the Quit Tobacco Program to seek smoking cessation treatment in the next 30 days * willing to make a quit attempt within 30 days of enrollment in the Quit Tobacco Program * willing to have a blood test to inform their treatment * willing to try a pharmacologic treatment * willing to provide a saliva sample * has phone service * has access to broadband internet on mobile phone at home, work, or other location * has an Android or iPhone mobile phone compatible with the Smokerlyzer app (Staff) \- Staff participants of qualitative interviews to assess acceptability and feasibility of the intervention must be a health care professional at Southcentral Foundation (SCF), involved in the care of one of the participants of the study, that is their care team staff; including but not limited to: primary care providers, tobacco treatment specialists/health educators, pharmacists, nurse case managers, behavioral health consultants, certified medical assistants, and lab technicians. Exclusion Criteria: (Patients) * Participated in the prior study phase * participated in a cessation program during the past 3 months * their provider has not approved varenicline in their referral to the Quit Tobacco Program * has history of serious hypersensitivity or skin reactions to varenicline * has bleeding disorder or is currently receiving cancer treatment * questionable capacity or impaired decision-making capacity