Searching for Novel Therapeutic Approaches in Migraine Patients Resistant to Treatments
Recruiting
Observational Study
Migraine Disorders
Chronic Migraine
Episodic Migraine
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
At a Glance
- Age
- 18 – 75
- Sex
- Any
- Study type
- Observational
- Participants needed
- 45 (estimated)
- Sponsor
- IRCCS National Neurological Institute "C. Mondino" Foundation · Other
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About This Trial
Primary working hypothesis is that NON-responders to mAbs bear a dysfunction of the endocannabidiome system (eCBome), as suggested by pre-clinical and clinical data by our group.
They will be identified as patients showing a reduction of monthly migraine days \< 50% after three months of treatment.
The clinical, biochemical and neurofunctional impact of novel therapeutic approaches expected to i…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* male and female patients aged 18 to 75 years
* diagnosis of episodic migraine or chronic migraine according to ICHD-3 criteria
* for episodic migraine: 8-14 monthly migraine days in the previous 3 months
* diagnosis of resistant migraine, defined by having failed at least 3 cl…
Contacts