Mortality and Cardiovascular Diseases in Adult-onset Type 1 Diabetes
Recruiting
Observational Study
Type 1 DiabetesType 2 Diabetes
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
18 – 110
Sex
Any
Study type
Observational
Participants needed
900,000 (estimated)
Sponsor
Karolinska Institutet · Other
Who this trial is looking for
This trial is looking for adults diagnosed with type 1 diabetes to learn more about their health risks. Participants will be compared with those who have type 2 diabetes and healthy individuals to understand factors that affect their health outcomes.
Are You a Good Fit for This Trial?
You may be able to join if
I am at least 18 years old.
I have been diagnosed with type 1 diabetes between 2001 and 2020.
I have been diagnosed with type 2 diabetes between 2001 and 2020.
You may not be able to join if
I have been diagnosed with cancer in the digestive system within a year before my diabetes diagnosis.
I have pancreatic cancer as the cause of death.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer a few quick questions to see if you may meet the eligibility requirements.
Scarce evidence is available for prognosis in adult-onset type 1 diabetes (T1D). The aim of this study is to investigate the risk of all-cause mortality, cause-specific mortality, and incident CVD in adult-onset T1D, as compared to type 2 diabetes with comparable age at diagnosis and population controls. We will explore potential modifiable factors including lifestyle and clinical characteristics …
Scarce evidence is available for prognosis in adult-onset type 1 diabetes (T1D). The aim of this study is to investigate the risk of all-cause mortality, cause-specific mortality, and incident CVD in adult-onset T1D, as compared to type 2 diabetes with comparable age at diagnosis and population controls. We will explore potential modifiable factors including lifestyle and clinical characteristics that contribute to T1D prognosis. In addition, we will estimate the life expectancy associated with different age at T1D diagnosis as compared to population controls. This study will be based on people with diabetes recorded in Swedish National Diabetes Registers, with linkages to other nationwide registers to retrieve data on lifestyle factors, biomarkers, treatment and outcome information.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* people with adult-onset (≥18 years) T1D diagnosed in 2001-2020 from the National Diabetes Register
* all T2D cases diagnosed at age ≥18 years in 2001-2020 recorded in the National Diabetes Register
Everyone with T1D was matched by age, sex, and county to 50 population control…
Inclusion Criteria:
* people with adult-onset (≥18 years) T1D diagnosed in 2001-2020 from the National Diabetes Register
* all T2D cases diagnosed at age ≥18 years in 2001-2020 recorded in the National Diabetes Register
Everyone with T1D was matched by age, sex, and county to 50 population controls from the Total Population Register.
Exclusion Criteria:
* To avoid diabetes secondary to pancreatic cancer, we excluded people diagnosed with cancer in the digestive system 1 year prior to diabetes diagnosis and with pancreatic cancer as the underlying cause of death.
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