Surovatamig for Mature B-Cell Malignancies

A Study of AZD0486 Monotherapy or in Combination With Other Anti-Cancer Agents for Mature B-Cell Malignancies

Recruiting Phase 1 Phase 2 Interventional Study
Chronic Lymphocytic Leukaemia Small Lymphocytic Lymphoma Mantle-cell Lymphoma Large B-cell Lymphoma B-cell Non-Hodgkin Lymphoma
No Placebo Group Every participant receives an active treatment — no one gets a placebo. Prior Safety Data This treatment has already been tested in at least one earlier human trial.
Ready to participate?

Review the details below, then apply to join this clinical trial.

At a Glance
Age
18 and older
Sex
Any
Trial phase
Phase 1/2
Study type
Interventional
Purpose
Treatment
Participants needed
408 (estimated)
Sponsor
AstraZeneca · Industry
Who this trial is looking for

This trial is looking for people with certain types of blood cancers to test a new treatment called surovatamig. Participants will take the treatment alone or with other cancer drugs.

Are You a Good Fit for This Trial?

You may be able to join if

  • I have a performance status of 0 to 2.
  • I use contraception during treatment and for 90 days after.
  • I have confirmed CD19 expression if I had anti-CD19 therapy.
  • I have been diagnosed with chronic lymphocytic leukaemia (CLL) and need treatment.
  • I have a measurable site of my small lymphocytic lymphoma (SLL).
  • I have a low absolute lymphocyte count.
  • I have received at least one line of therapy if in the right cohort for CLL/SLL.
  • I am no older than 79 years of age.

You may not be able to join if

  • I have central nervous system lymphoma.
  • I had surgery within 14 days of starting the study.
  • I have significant cardiovascular disease.
  • I have unresolved severe side effects from previous treatments.
  • I received any systemic therapy within 5 half-lives or 21 days before starting.
  • I had radiation therapy within 28 days.
  • I had CAR T-cell therapy or stem cell transplant within 12 weeks.
  • I have an active, uncontrolled infection or autoimmune disease.

Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.

Think this trial could be right for you?

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About This Trial

The purpose of this study is to assess the safety and efficacy of surovatamig (formerly AZD0486) administered as monotherapy or in combination with other anticancer agents in participants with hematological malignancies

Trial Locations
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Eligibility Criteria
Inclusion Criteria: Master Inclusion Criteria applicable to all substudies: * Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 2. * Contraception use during treatment and at least 90 days after final dose. * Confirmed CD19 expression if prior anti-CD19 therapy. Substudy 1 Spec…
Contacts

AstraZeneca Clinical Study Information Center

1-877-240-9479

information.center@astrazeneca.com

CONTACT