Extracorporeal Shockwave Versus Phonophoresis Using Chitosan-Nanoparticles Gel on Functional and Anatomical Changes Detected With Artificial Intelligence Based Texture Analysis Algorithm in Knee Osteoarthritis Patients: A Double Blind Randomized Controlled Trial

Inclusion Criteria: 1. Age between ≥40 and ≤ 65 years old. 2. Both genders. 3. Patients should have OA of the knee, Kellgren-Lawrence scores of 2 and 3 on radiologic evaluation. 4. If both knees diagnosed as OA, the most affected one will be selected. 5. Diagnosis of KOA who had knee pain and functional disabilities for at least three months, according to American College of Rheumatology classification (ACR) at screening visit. 6. Visual Analogue Scale (VAS) at rest score of ≥40 mm. 7. Subjects have sufficient cognition that enables them to understand the requirements of the study, comply with the study procedures and visit schedule. Exclusion Criteria: 1. Patients with any previous knee surgeries or lower limb fractures. 2. Chronic inflammatory diseases such as rheumatoid arthritis. 3. Any neurological disorders. 4. Moderate to significant knee synovitis. 5. Hot or red knee. 6. History and/or physical examination findings compatible with the internal derangement of knee. 7. Pregnancy. 8. Patients with BMI more than 35 (morbid obesity). 9. Absence of current physical therapy treatments for KOA. 10. Cognitive limitations or endocrine disease. 11. Patients who had undergone arthroscopy or treatment with intra-articular hyaluronic acid during previous 6 months. 12. Use of NSAIDs one week prior to screening visit. 13. Orthopedic diseases that may affect or interfere with the therapeutic effect. 14. Habitual use of psychotropic or narcotic analgesics for ≥1 week within 8 weeks prior to screening. 15. Participated in other intervention studies on the past 6 months to screening 16. Participants with congenital musculoskeletal deformity.