Brain Activity During Sexual Behavior in Patients With Primary Premature Ejaculation a Clinical Trial

Inclusion Criteria (primary premature ejaculation subjects): * patients' age varied from 18 to 45 years； * patients met the 2014 International Society for Sexual Medicine (ISSM) definition criteria for PPE； * patients had a stable, heterosexual relationship with a single sexually active female partner for at least 6 months and with at least two sexual intercourses a week and kept stable during the study period; * Patients with premature ejaculation lasting longer than 6 months； * patients were identified if their scores were higher than 9 on the Chinese version of Premature Ejaculation Diagnostic Tool (PEDT); * patients had no history of any previous therapies for PE or had recently stopped the therapies for at least 3 months * patients had fully informed consent, signed informed consent form Inclusion Criteria (Non-premature ejaculation subjects): * Men between the ages of 18-45 years were included according to an age difference of \<3 years between each patient and the primary premature ejaculation group, and if more than one volunteer was eligible at the same time, the one with the closest age was selected； * Patient does not meet the 2014 International Society for Sexual Medicine (ISSM) criteria for defining premature ejaculation； * patients had a stable, heterosexual relationship with a single sexually active female partner for at least 6 months and with at least two sexual intercourses a week and kept stable during the study period; * patients had fully informed consent, signed informed consent form； Exclusion Criteria: * patients were diagnosed with secondary PE, variable PE, and subjective PE; * patients were using medications for endocrinological, metabolic, chronic systemic, or psychiatric diseases; * patients were abusing alcohol or illegal drugs； * patients were diagnosed with erectile dysfunction (ED) if their scores were \<21 on the abridged five-item International Index of Erectile Function (IIEF-5) * patients were diagnosed with sexual hormone abnormalities, hyperthyroidism, hypothyroidism, Peyronie's disease, prostatitis, urethritis, or urinary tract infection; * patients with head injuries that prevent them from completing near-infrared light brain function imaging * Patients with severe schizophrenia, anxiety, depression or other neurological symptoms or poor compliance