No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
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At a Glance
Age
18 and older
Sex
Female
Study type
Interventional
Purpose
Treatment
Participants needed
90 (estimated)
Sponsor
Integrative Skin Science and Research · Industry
Who this trial is looking for
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Investigate the topical use of almond oil, almond oil augmented with 0.5% vitamin E, 0.025% tretinoin oil augmented with castor oil on the appearance of facial fine lines and wrinkles, pigmentation, hydration, trans-epidermal water loss, and sebum excretion rate.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Post-menopausal women of Fitzpatrick skin types 1, 2, and 3
* Individuals with facial fine lines and wrinkles
Exclusion Criteria:
* Individuals who are pregnant or breastfeeding
* Prisoners
* Adults unable to consent
* Those with a nut allergy or tocopherol allergy
* Current…
Inclusion Criteria:
* Post-menopausal women of Fitzpatrick skin types 1, 2, and 3
* Individuals with facial fine lines and wrinkles
Exclusion Criteria:
* Individuals who are pregnant or breastfeeding
* Prisoners
* Adults unable to consent
* Those with a nut allergy or tocopherol allergy
* Current smokers, those that have smoked within the past year, and former smokers with greater than a 10-pack- year history of smoking
* Those with an autoimmune photosensitive condition or a known genetic condition with a deficiency in collagen production (such as Ehlers-Danlos syndromes)
* Those who have undergone any cosmetic procedures to the face in the 3 months prior to enrollment in the opinion of the investigator. People that have undergone deeper chemical peels (TCA based peels) within 1 year prior to enrollment
* Individuals who are unwilling to discontinue vitamin E containing supplements and food sources such as all nuts, sunflower seeds or sunflower oil during the washout and intervention
* Individual who are unwilling to discontinue topical cosmetic products during the duration of the study or unwilling to undergo a 2-week washout of topicals that are known to modulate collagen and pigment:
* Retinoids such as tretinoin, adapalene, retinol, except as provided by the study.
* Antioxidant ingredients such as vitamin C or vitamin E.
* Pigment reducing agents such as hydroquinone, azelaic acid, kojic acid, or a retinoid except for the retinol that is provided in this study.
* Topicals that contain a nut oil or nut extract as part of their ingredient list.
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