Optimizing Recruitment to Drive Equitable Research Opportunity in Stroke Rehabilitation Trials in Canada

Inclusion Criteria: 1. Primary ischemic anterior circulation stroke 2. Age ≥18 years 3. ≥5 days but \<8 weeks after stroke on the date of medication (Maraviroc or placebo) start 4. Hemiparesis requiring inpatient rehabilitation 5. Assistance available for daily rehabilitation training practice and for transportation when needed 6. Adequate language skills to understand Informed Consent and retain information during daily therapies 7. At least one of the following: some shoulder abduction with gravity eliminated and visible extension in two or more digits OR visible hip flexion or extension Exclusion Criteria: 1. Pre-stroke modified Rankin score ≥2 2. Limited resources or illness that will not enable a return to living outside of a facility 3. History of dementia 4. History of hepatitis or elevated hepatic transaminases or bilirubin 5. History of renal insufficiency or creatinine clearance (eGFR) \<60mL / min / 1.73m2 6. Cancer or other chronic illness that makes 1-year survival unlikely or will detract from the ability to carry out exercise and skills practice 7. Existing pre-stroke serious disabling disease (e.g., Parkinson's disease, severe traumatic brain injury, amputation) 8. Seizure related to stroke 9. Acute or chronic epilepsy 10. Currently taking any of the following anticonvulsant medications: Carbamazepine, Phenobarbital, Phenytoin 11. Pregnant, breastfeeding, or positive test for pregnancy at baseline 12. Women of childbearing potential who are not using one highly effective form of contraception or two forms of effective contraception 13. Known HIV positivity 14. Currently taking any of the following antifungal and/or antibacterial medications: Ketoconazole, Itraconazole, Voriconazole, Rifampin, Clarithromycin, Rifabutin + Protease Inhibitor 15. Currently taking St. John's Wort