Prospective Evaluation Of Delayed Effects Of Pediatric Car T Cell Therapy
Recruiting
Observational Study
B-ALLHematologic MalignancySolid Tumor
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
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At a Glance
Age
Up to 30
Sex
Any
Study type
Observational
Participants needed
100 (estimated)
Sponsor
St. Jude Children's Research Hospital · Other
Who this trial is looking for
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This study is being done to learn more about the short-term and long-term side effects of CAR-T cell therapy. Specifically, researchers want to know how often patients get infections, have delays in recovering blood cell counts and/or have damage to the nervous system.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Participants must have received an initial systemically-administered CAR T cell infusion within the last 1-3 months (+/- 14 days).
* Initial infusion is defined as the first administration of a CAR T cell product the participant has not previously received OR receipt of a C…
Inclusion Criteria:
* Participants must have received an initial systemically-administered CAR T cell infusion within the last 1-3 months (+/- 14 days).
* Initial infusion is defined as the first administration of a CAR T cell product the participant has not previously received OR receipt of a CAR T cell product previously received after an interval allogeneic HSCT.
* Age ≤ 30 years at CAR T cell infusion.
Exclusion Criteria:
* Active malignancy other than the disease under study.
* Planned consolidative HSCT within 3 months post CAR T cell infusion.
* Received or planned additional disease directed therapy post CAR T cell infusion.
* Inability or unwillingness of research participant or legal guardian/representative to give written informed consent.
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