Genetics and Environment iNtersection In the ALS-FTD Spectrum: an Italian Twins Cohort studY With a Multi-Omics Approach
Recruiting
Observational Study
ALS
FTD
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
At a Glance
- Age
- 18 and older
- Sex
- Any
- Study type
- Observational
- Participants needed
- 45 (estimated)
- Sponsor
- Azienda Ospedaliero-Universitaria di Modena · Other
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About This Trial
The goal of this study is to learn from discordant twins affected by Amyotrophic Lateral Sclerosis and/or Frontotemporal Dementia the contribution of genetic background versus environmental exposure. The main questions it aims to answer is:
* How far does the genetic background explain the onset of ALS/FTD in discordant twins?
* Which environmental factors and events occurring in post-fetal life …
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Age \>18 yrs
* Presence of MZ or DZ twins in the family both willing to participate in the study and able to provide informed consent
* At least one twin is affected by ALS as defined by Gold Coast Criteria (Shefner et al., 2020) and/or by FTD as defined by Strong and colle…
Contacts