Evaluation of the Performance and Acceptability of a Synthetic Polyisoprene Male Condom Compared to a Natural Rubber Latex Condom

Inclusion Criteria: 1. Between the ages of 18 and 45 (inclusive) 2. Willing and able to give written or electronic informed consent 3. Willing to respond to questions concerning their reproductive and contraceptive history and use of condoms contained either on self-administered questionnaires or interviews 4. Be sexually active (defined as averaging one vaginal coital act per week) 5. Protected against pregnancy by oral contraceptives, an IUD, an implant, contraceptive injections, contraceptive patch, or sterilization (tubal ligation or vasectomy) 6. Willing to use the study products for ten acts of vaginal intercourse within six weeks of study entry 7. In a mutually monogamous relationship with their study partner for at least 3 months and be willing to remain mutually monogamous throughout study participation 8. Agree not to use any vaginal or sexual lubricant except the product supplied by the study 9. Agree not to wear any genital piercing jewelry while using the study condoms 10. Agree not to use sex toys or drugs intended to enhance or diminish sexual response when using study condoms 11. Agree to return any unopened condoms 12. Reachable by telephone 13. Has home internet access, a valid personal email for each partner, reachable by phone, ability to videoconference and use electronic consent technology 14. Male partner agrees to ejaculate during vaginal intercourse 15. Willing to provide photo identification- Exclusion Criteria: 1. Currently participating in another similar clinical study or employed by a condom manufacturer or Essential Access Health 2. Female partner self-reported as pregnant 3. Allergic to natural rubber latex or polyisoprene, or has a history of recurrent adverse events following use of latex or polyisoprene products 4. Unable to follow instructions or strictly adhere to the visit schedule 5. At significant (high) risk of sexually transmitted infections, including HIV infection, or having a medical history of recurrent, serious sexually transmitted infection (e.g. gonorrhea, syphilis, Chlamydia) 6. Currently using condoms for protection against a known sexually transmitted infection 7. Taking any internally applied medication or oral medication to treat a genital condition 8. Male partner has had difficulty achieving or maintaining an erection, or achieving ejaculation in the last month under typical circumstances/ conditions. 9. Any self-reported genital condition (e.g. itching, burning, irritation, etc.) which, in the opinion of the investigator, could affect use of the study condoms or the ability to interpret study data -