No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
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At a Glance
Age
20 and older
Sex
Any
Study type
Interventional
Purpose
Treatment
Participants needed
60 (estimated)
Sponsor
Chang Gung University · Other
Who this trial is looking for
This trial is looking for people diagnosed with Parkinson's disease who have difficulty starting to walk. Participants will take part in training aimed at improving balance and walking skills.
Are You a Good Fit for This Trial?
You may be able to join if
I have been diagnosed with Parkinson's disease
You may not be able to join if
I have musculoskeletal injuries on my legs
I have osteoporosis
I have any peripheral or central nervous system injury or disease
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer a few quick questions to see if you may meet the eligibility requirements.
Gait initiation (GI) difficulty is a common problem in individuals with Parkinson's disease (PD), often linked to impaired anticipatory postural adjustments (APA). Currently, there are no targeted rehabilitation programs designed specifically for GI-related APA in PD patients. Research has shown that while motor learning deficits are common in PD, explicit learning is better preserved than implici…
Gait initiation (GI) difficulty is a common problem in individuals with Parkinson's disease (PD), often linked to impaired anticipatory postural adjustments (APA). Currently, there are no targeted rehabilitation programs designed specifically for GI-related APA in PD patients. Research has shown that while motor learning deficits are common in PD, explicit learning is better preserved than implicit learning. Therefore, a GI-related APA training system using an explicit learning model could be particularly effective for this population.
During motor learning, long-term potentiation (LTP) increases the excitability of the primary motor cortex. Paired associative stimulation (PAS) has been demonstrated to induce LTP-like changes in the motor cortex, making it a potential priming method to enhance motor learning. However, the priming effect of PAS targeted at leg muscles and the motor cortex on motor learning related to GI-APA has not been previously studied.
The objectives of this study are:
1. To investigate the effects of explicit and implicit training on GI-related APA.
2. To evaluate the priming effect of PAS on GI-related APA training and the associated plasticity changes in the motor cortex.
Trial Locations
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Status
Eligibility Criteria
Inclusion Criteria:
\- Clinical diagnosis of Parkinson disease.
Exclusion Criteria:
* Musculoskeletal injuries on legs
* Osteoporosis.
* Any peripheral or central nervous system injury or disease patients.
Inclusion Criteria:
\- Clinical diagnosis of Parkinson disease.
Exclusion Criteria:
* Musculoskeletal injuries on legs
* Osteoporosis.
* Any peripheral or central nervous system injury or disease patients.
Contacts
No contact information available.
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