Greater Manchester CARDIOvascular Pathology in Immune-Mediated Inflammatory Diseases

Main Study Inclusion Criteria: * Males and females * Subjects aged over 18 years * Capable of providing informed consent and signing a consent form * Have a clear diagnosis of an IMID with history consistent with one of the following categories: * IMID-'at risk' CVD: individuals who have a risk of developing CVD (based on traditional risk factors and/or IMID-specific factors) but no history of major adverse cardiovascular events (MACE). * Incident (new) IMID-CVD: Patients with IMID that present with a MACE. * Established IMID-CVD: Patients with IMID and a history of previous MACE Exclusion Criteria: * Age less than 18 years * Lack of capacity to give informed consent Imaging Sub-Study Inclusion Criteria: \- As-listed for Main Study Exclusion Criteria: * As-listed for Main Study and; * For the research cardiac MRI imaging component, the following exclusions will apply: pacemakers, surgical clips within the head, certain inner ear implants, neuro-electrical stimulators or metal fragments within the eye or head, pregnancy or breast-feeding. For administration of gadolinium-based contrast agent, GFR \< 30 ml/min/1.73 m2 is a contraindication. Biological Sub-Study Inclusion Criteria: \- As-listed for Main Study Exclusion Criteria: \- As-listed for Main Study Controls Inclusion Criteria: * Subject ≥ 18 years of age * Is capable of understanding and signing an informed consent form * No known diagnosis of an IMID (CVD-no IMID disease control and healthy control groups) * No known diagnosis of CVD (IMID-no risk CVD disease control and healthy control groups) Exclusion Criteria: * As-listed for Main Study and; * For the research cardiac MRI imaging component, the following exclusions will apply: pacemakers, surgical clips within the head, certain inner ear implants, neuro-electrical stimulators or metal fragments within the eye or head, pregnancy or breast-feeding. For administration of gadolinium-based contrast agent, GFR \< 30 ml/min/1.73 m2 is a contraindication. For Healthy controls: The researchers will aim to identify healthy controls using the 'bring a friend' strategy where the patient is asked to bring a friend/relative, thus minimising demographic bias. This will establish a healthy control pool. For specific analyses, controls will be age and sex matched and where possible, BMI-matched to the specific study population.