Vitamin C and Cordyceps for Chemotherapy Related Anemia
Vitamin C Plus Cordyceps to Chemotherapy Related Anemia in Pancreatic Cancer
Recruiting
Phase 2Phase 3Interventional Study
Pancreatic Cancer
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Pivotal Trial
This treatment is in the last trial phase before FDA approval.
Prior Safety Data
This treatment has already been tested in at least one earlier human trial.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
18 – 80
Sex
Any
Trial phase
Phase 2/3
Study type
Interventional
Purpose
Treatment
Participants needed
50 (estimated)
Sponsor
Fudan University · Other
Who this trial is looking for
This trial is looking for adults with metastatic pancreatic cancer who are receiving chemotherapy. Participants will receive low-dose vitamin C and herbal medicine to see if it improves their quality of life.
Are You a Good Fit for This Trial?
Rules you outPancreatitisCholecystitisCholangitisG6PD deficiencySevere infectionsUncontrolled hypertensionHeart failureCerebral infarction
You may be able to join if
I am between 18 and 80 years old.
I understand and am willing to sign a consent form.
I have been diagnosed with metastatic pancreatic cancer.
I have a hemoglobin level of at least 8 g/dL.
I expect to live for at least 3 months.
I have at least one measurable tumor.
I am in fair health based on lab tests.
I will use contraception if I can have children.
You may not be able to join if
I have received treatment for another type of cancer in the last 2 years.
I have had treatment for pancreatic cancer before.
I have an active inflammation of my digestive tract.
I am pregnant or nursing.
I have a severe illness that affects my safety in the study.
I have renal insufficiency or need dialysis.
I have had allergic reactions to similar medications.
I cannot comply with the study procedures.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer a few quick questions to see if you may meet the eligibility requirements.
The purpose of this study is to evaluate the efficacy of low-dose vitamin C plus herbal medicine on improving the quality of life for metastatic pancreatic cancer patients receiving gemcitabine and nab-paclitaxel chemotherapy.
Trial Locations
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Status
Eligibility Criteria
Inclusion Criteria:
* • Ability to understand and the willingness to sign a written informed consent document.
* Age ≥ 18 years and ≤ 80 years.
* Eastern Cooperative Oncology Group (ECOG) performance status 0-2.
* Histologically or cytologically confirmed metastatic pancreas adenocarcinoma.
…
Inclusion Criteria:
* • Ability to understand and the willingness to sign a written informed consent document.
* Age ≥ 18 years and ≤ 80 years.
* Eastern Cooperative Oncology Group (ECOG) performance status 0-2.
* Histologically or cytologically confirmed metastatic pancreas adenocarcinoma.
* Adequate organ performance based on laboratory blood tests.
* Presence of at least of one measurable lesion in agreement to RECIST criteria.
* Hemoglobin (Hgb) ≥ 8 g/dL.
* The expected survival ≥ 3 months.
* Women of childbearing potential and men must agree to use adequate contraception prior to study entry and for the duration of study participation.
Exclusion Criteria:
* • Patients who have received anti-tumor treatment for other types of cancer in the last two years.
* Patients who have received any form of anti-tumor therapy for pancreatic cancer.
* The diagnosis was confirmed by pathology as non-adenocarcinoma of pancreas.
* Inflammation of the digestive tract, including pancreatitis, cholecystitis, cholangitis, etc.
* Pregnant or nursing women.
* Glucose-6-phosphate dehydrogenase (G6PD) deficiency.
* Severe and uncontrollable accompanying diseases that may affect protocol compliance or interfere with the interpretation of results, including active opportunistic infections or advanced (severe) infections, and diabetes that cannot be controlled after adequate clinical anti-hyperglycemia treatment according to guidelines, uncontrollable hypertension, cardiovascular disease (Class III or IV heart failure as defined by the New York Heart Association classification, congestive heart failure (CHF), myocardial infarction in the past 6 months , unstable arrhythmia or unstable angina, cerebral infarction within 3 months, etc).
* Renal insufficiency or dialysis
* History of allergic reactions attributed to compounds of similar chemical or biologic composition to gemcitabine, nab-paclitaxel, or other agents used in the study.
* Other serious accompanying illnesses, which, in the researcher\'s opinion, could seriously adversely affect the safety of the treatment.
* Patients who are unwilling or unable to comply with study procedures.
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