Electroacupuncture Combined With Self-administered Acupressure for the Prevention of Capecitabine-Associated Hand-Foot Syndrome

Inclusion Criteria: 1. Sign a written informed consent form; 2. Male or female ≥ 18 years old; 3. Patients with gastrointestinal cancer or breast cancer who are diagnosed with cancer by pathology will receive capecitabine treatment for the first time according to the label; 4. The performance status of the Eastern Cancer Collaboration Group is 0-2; 5. Palliative or adjuvant chemotherapy with capecitabine (combination or monotherapy, minimum daily total dose of capecitabine 2000 mg/m\^2); 6. Expected lifespan ≥ 3 months; 7. Laboratory requirements: platelet count ≥ 100 × 10\^9/L, white blood cell count\>3.0 × 10\^9/L, hemoglobin ≥ 10.0 g/dL, normal liver and kidney function; 8. Adequate contraception. Exclusion Criteria: 1. Previous use of capecitabine or liposome doxorubicin or any other tyrosine kinase inhibitor that may induce HFS (such as sorafenib, sunitinib, and apatinib) for chemotherapy; 2. The initial dose of capecitabine is less than 800mg/m\^2; 3. Radiation therapy or surgery should be performed within 4 weeks before the start of treatment; 4. Skin diseases that may interfere with clinical trial results; 5. Known drug/alcohol abuse; 6. Pregnant women or lactating patients; 7. Participate in another clinical trial and the patient has received the investigational drug within the last 30 days prior to the start of treatment (i.e. follow-up in the previous trial was not exclusive); 8. Known patients who are afraid of electroacupuncture stimulation or allergic to stainless steel needles or any component of capecitabine; 9. Receive any acupuncture and moxibustion treatment ,there is lymphedema in the area stimulated by acupuncture; 10. Patients with any chemotherapy- or radiotherapy-related toxicities that have not subsided to grade 2 or lower will be excluded, except for stable sensory neuropathy. 11. Any unresolved skin toxicity caused by previous chemotherapy or radiotherapy, except for hair loss, will also be grounds for exclusion.