Understanding Brain's Role in Sleep Apnea
Unveiling the Neural Mechanisms of 5-HT7 in Sleep Apnea Induced by Arousal Dysregulation
Recruiting
Observational Study
Obstructive Sleep Apnea
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
At a Glance
- Age
- 20 – 60
- Sex
- Any
- Study type
- Observational
- Participants needed
- 140 (estimated)
- Sponsor
- Beijing Tsinghua Chang Gung Hospital · Other
Who this trial is looking for
This trial is looking for adults with obstructive sleep apnea, simple snorers, and healthy individuals. Participants will help researchers study how certain brain pathways affect sleep breathing and arousal during sleep.
Are You a Good Fit for This Trial?
You may be able to join if
- I am between 20 and 60 years old.
- I have symptoms of sleep snoring.
- I feel sleepy during the day.
- I have been diagnosed with obstructive sleep apnea.
- I do not have obstructive sleep apnea but snore.
- I do not have any symptoms of sleep snoring and have normal sleep.
You may not be able to join if
- I have severe lung, brain, or heart problems.
- I have used a breathing machine for more than 3 months.
- I have had surgery on my upper airways.
- I have sleep-breathing problems for special reasons like thyroid issues.
- I have severe mental health issues or long-term alcohol abuse.
- I have central sleep apnea due to other issues.
- I have severe facial deformities or muscle diseases.
- I have peripheral nerve issues from diabetes or other diseases.
Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.
Think this trial could be right for you?
Answer a few quick questions to see if you may meet the eligibility requirements.
Check Your Eligibility
About This Trial
Obstructive sleep apnea (OSA), recognized as a highly prevalent sleep breathing disorder with severe complications, features a complex etiology. Poor understanding of disease pathogenesis limits the overall efficacy of interventions. Studies have found that upregulation of 5-HT7 expression in the lateral hypothalamus (LH) could reduce arousal threshold (ArTH) and induce an inhibitory effect to the…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
OSA Patients:
* Age between 20 and 60 years.
* Symptoms of sleep snoring and daytime sleepiness.
* Confirmed diagnosis of OSA following overnight sleep monitoring.
Simple Snorers:
* Age between 20 and 60 years.
* Symptoms of sleep snoring.
* Overnight sleep monitoring indicat…
Contacts