BHB & CAR-T for Lymphomas

Recruiting N/A Interventional Study
Large B-cell Lymphoma
No Placebo Group Every participant receives an active treatment — no one gets a placebo.
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At a Glance
Age
18 and older
Sex
Any
Study type
Interventional
Purpose
Treatment
Participants needed
5 (estimated)
Sponsor
Abramson Cancer Center at Penn Medicine · Other
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About This Trial
The aim of this study is to assess the feasibility of β-hydroxybutyrate (BHB) supplementation in individuals who are receiving therapy for lymphoma with standard-of-care anti-CD19 CAR T-cells (CAR-T) to determine whether BHB supplementation is safe and tolerable in this patient population. Additionally, this study will determine whether BHB supplementation leads to changes the gut microbiome and p…
Trial Locations
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Eligibility Criteria
Inclusion Criteria: * Age of 18 years or older * History of pathologically-confirmed large B-cell lymphoma (LBCL) * Planned treatment with a commercially available anti-CD19 CAR-T product (Yescarta or Kymriah) * Eligible for and with adequate organ function (investigator discretion) and performance…
Contacts

Brittany Koch, MPH

215-615-4312

Brittany.Koch@pennmedicine.upenn.edu

CONTACT

Kaitlin Kennard, BSN, RN

267-804-4080

Kaitlin.Kennard@pennmedicine.upenn.edu

CONTACT