No Study Drug
Researchers observe your health over time — no experimental treatment is given.
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At a Glance
Age
18 and older
Sex
Any
Study type
Observational
Participants needed
180 (estimated)
Sponsor
Imperial College London · Other
Who this trial is looking for
This trial is looking for adults with chronic lung disease to help understand how viruses may trigger flare-ups. Participants will provide samples when they feel unwell and visit the researchers for more tests over the course of two years.
Are You a Good Fit for This Trial?
You may be able to join if
I have been diagnosed with chronic airway disease like COPD or bronchiectasis.
I have had a disease flare-up in the last year.
You may not be able to join if
I cannot keep daily symptom diaries.
I have had a flare-up within the last 4 weeks.
I am pregnant.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer a few quick questions to see if you may meet the eligibility requirements.
Many people with chronic lung disease have disease flare-ups. It was previously believed that these were mainly caused by bacteria but recent evidence suggests that viruses could be an important trigger. This study will recruit volunteers with chronic lung disease and take samples both when well (at baseline) and during flare-ups (exacerbations) to better understand the role of viruses in triggeri…
Many people with chronic lung disease have disease flare-ups. It was previously believed that these were mainly caused by bacteria but recent evidence suggests that viruses could be an important trigger. This study will recruit volunteers with chronic lung disease and take samples both when well (at baseline) and during flare-ups (exacerbations) to better understand the role of viruses in triggering exacerbations and also how the immune response is affected. The researchers will follow the volunteers\' progress for up to two years. Whenever they get unwell they will take some samples (nose swabs, finger prick testing, phlegm sample) and post them to the researchers. Then, they will come in for a visit for more samples (blood tests, further swabs) and a review.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Adults with a physician confirmed diagnosis of chronic airway disease (e.g. COPD and bronchiectasis) according to established diagnostic criteria.
AND
\- Prior history of exacerbation within last year (defined as requiring antibiotic and/or corticosteroids).
Exclusion Crite…
Inclusion Criteria:
* Adults with a physician confirmed diagnosis of chronic airway disease (e.g. COPD and bronchiectasis) according to established diagnostic criteria.
AND
\- Prior history of exacerbation within last year (defined as requiring antibiotic and/or corticosteroids).
Exclusion Criteria:
* Inability to complete daily symptom diaries and/or attend for clinical assessments.
* Exacerbation within 4 weeks of study recruitment and/or clinical instability at the time of recruitment.
* Pregnancy.
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