Identification of Innovative Biomarkers Related to the Immune System or Tumor Microenvironment to Promote the Efficacy of Immunotherapies

INCLUSION CRITERIA: General inclusion criteria: * Patients ≥ 18 years old * more than 6 months of life expectancy as assessed by the investigator * Performance status ECOG 0 ; 1 or 2 * Patient affiliated to or beneficiary of French social security system * Informed consent of the subject to participate in the study Specific eligibility criteria: \- Cohort A \[Patients with advanced digestive or gynecological cancers eligible to immunotherapies\]: Patients with locally advanced or metastatic digestive or gynecological cancers A1: hepatocellular carcinoma eligible to immunotherapy ± antiangiogenic A2: biliary tract carcinoma eligible to chemo-immunotherapy A3: oesogastric carcinoma eligible to chemo-immunotherapy A4: other digestive localizations eligible to immunotherapy (anti-PD1/PDL1 ± anti-CTLA4) ± chemotherapy A5: gynecological cancers eligible to chemo-immunotherapy \- Cohort B \[Patients with advanced digestive or gynecological cancers eligible to chemotherapy or targeted therapy without immunotherapy\]: Patients with locally advanced or metastatic digestive or gynecological cancers B1: hepatocellular carcinoma eligible to antiangiogenic or chemotherapy B2: biliary tract carcinoma eligible to chemotherapy B3: oesogastric carcinoma eligible to chemotherapy B4: other digestive localizations eligible to chemotherapy and/or targeted therapy B5: gynecological cancers eligible to chemotherapy and/or targeted therapy \- Cohort C \[Patients with advanced digestive or gynecological cancers eligible to surgery of metastasis after chemotherapy\]: Patients with liver metastasis of colorectal cancer or peritoneal metastasis of ovarian cancer eligible to surgical resection EXCLUSION CRITERIA : General exclusion criteria: * Patient under guardianship, curatorship or under the protection of justice * Patient with any medical or psychiatric condition or disease, which would make the patient inappropriate for entry into this study * Patient unlikely to cooperate with the study and/or poor cooperation anticipated by the investigator * Patient without health insurance * Pregnant women * Subject within the exclusion period of another study or planned by the national volunteer file