Renal Arterial Resistive Index as a Noninvasive Biomarker of Disease Activity in Lupus Nephritis Patients
Recruiting
Observational Study
Lupus Nephritis
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
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Review the details below, then apply to join this clinical trial.
At a Glance
Age
18 – 50
Sex
Any
Study type
Observational
Participants needed
55 (estimated)
Sponsor
Sohag University · Other
Who this trial is looking for
This trial is looking for adults with lupus nephritis to study a test that can help measure disease activity. Participants will need to answer questions and provide consent.
Are You a Good Fit for This Trial?
You may be able to join if
I am 18 years or older.
I have been diagnosed with systemic lupus erythematosus.
I can answer questions.
I am willing to give written informed consent.
You may not be able to join if
I have another autoimmune disease.
I have diabetes.
I have high blood pressure.
I have heart failure.
I have liver disease.
I have chronic kidney failure.
I have renal artery stenosis.
I am unable to give written informed consent.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
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Systemic Lupus Erthymatosous (SLE) is achronic inflammatory multi system auto immue disease characterized by pathogenic auto anti bodies production against nuclear structures (Bolouri et al.,2022), SLE affecting mainly woemn of childbearing age and is chracterized by unpredictable flares and remissions , disease variety varied from mild episode disorder to arpidly progressive life -threatening ill…
Systemic Lupus Erthymatosous (SLE) is achronic inflammatory multi system auto immue disease characterized by pathogenic auto anti bodies production against nuclear structures (Bolouri et al.,2022), SLE affecting mainly woemn of childbearing age and is chracterized by unpredictable flares and remissions , disease variety varied from mild episode disorder to arpidly progressive life -threatening illness..
LN is diagnosed by either the presence of proteinuria \>0.5g/day. active urinary sediment , or an unexplained rise in serum creatinine there fore , identifying new invasive biomarkers of LN severity and outcome is mandatory, Renal Arterial resistive index ( RRI) is anon invasive biomarker that has been studied as apotential indicator of disease activity in LN patients.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Aged ≥18 years.
* SLE patients fulfilling the SLE International Collaborating Clinics (SLICC) classification criteria and matched controls.
* Patients cooperative and can answer questions.
* Patients who are able and willing to give written informed consent.
Exclusion Criteri…
Inclusion Criteria:
* Aged ≥18 years.
* SLE patients fulfilling the SLE International Collaborating Clinics (SLICC) classification criteria and matched controls.
* Patients cooperative and can answer questions.
* Patients who are able and willing to give written informed consent.
Exclusion Criteria:
* • Individuals with other autoimmune diseases.
* Diabetes.
* Hypertension.
* Heart failure.
* Hepatic diseases.
* Chronic renal failure.
* Renal artery stenosis.
* Renal vein thrombosis.
* Intrarenal arteriovenous fistula.
* Obstructive nephropathy.
* Urinary tract obstruction that could affect RI of intra renal arteries.
* Un cooperative patients.
* Patients not able and willing to give written informed consent.
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