Sonelokimab for Active Psoriatic Arthritis

Evaluation of Sonelokimab in Patients With Active Psoriatic Arthritis and Anti-TNFα Inadequate Response

Recruiting Phase 3 Interventional Study
Arthritis, Psoriatic
Pivotal Trial This treatment is in the last trial phase before FDA approval. Prior Safety Data This treatment has already been tested in at least one earlier human trial.
Ready to participate?

Review the details below, then apply to join this clinical trial.

At a Glance
Age
18 and older
Sex
Any
Trial phase
Phase 3
Study type
Interventional
Purpose
Treatment
Participants needed
600 (estimated)
Sponsor
MoonLake Immunotherapeutics AG · Industry
Who this trial is looking for

This trial is looking for adults with active psoriatic arthritis who did not respond well to past treatments. Participants will take sonelokimab or a placebo to see how well it works and if it is safe.

Are You a Good Fit for This Trial?

You may be able to join if

  • I am at least 18 years old.
  • I have been diagnosed with psoriatic arthritis for at least 6 months.
  • I have active psoriatic arthritis with at least 3 tender and 3 swollen joints.
  • I currently have plaque psoriasis or a history of it confirmed by a dermatologist.
  • I have tested negative for rheumatoid factor and anti-cyclic citrullinated peptide.
  • I have received at least one TNFα inhibitor and did not respond well or stopped due to side effects.

You may not be able to join if

  • I am allergic to sonelokimab or its ingredients.
  • I have an allergy to risankizumab or its components.
  • I have other chronic inflammatory conditions besides psoriasis or psoriatic arthritis.
  • I have inflammatory bowel disease.
  • I have had unexplained diarrhea for 3 weeks or more in the last 24 weeks.
  • I have been diagnosed with arthritis mutilans.
  • I have used sonelokimab before.
  • I have ever taken biologic treatments for psoriasis or psoriatic arthritis that do not target TNFα.

Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.

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About This Trial

This is a study to confirm the clinical efficacy and safety of sonelokimab compared with placebo in the treatment of adults with active psoriatic arthritis who have had a previous inadequate response or intolerance to anti-tumor necrosis factor (TNF)α therapy.

Trial Locations
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Eligibility Criteria
Inclusion Criteria: 1. Participants must be ≥18 years of age . 2. Participants have a confirmed diagnosis of psoriatic arthritis (PsA) per the 2006 Classification for Psoriatic Arthritis (CASPAR) criteria with symptoms for ≥6 months before the Screening Visit. 3. Participants have active disease (d…
Contacts

Moonlake Clinical Trial Helpdesk

+41 41 510 8022

ClinicalTrials@moonlaketx.com

CONTACT