Zr-89 Crefmirlimab Berdoxam and Immuno-Positron Emission Tomography for the Imaging of Patients With Resectable Brain Tumors

Recruiting Phase 1 Interventional Study
Glioma Malignant Brain Neoplasm Meningioma Metastatic Malignant Neoplasm in the Brain
No Placebo Group Every participant receives an active treatment — no one gets a placebo.
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At a Glance
Age
18 and older
Sex
Any
Trial phase
Phase 1
Study type
Interventional
Purpose
Diagnostic
Participants needed
20 (estimated)
Sponsor
Jonsson Comprehensive Cancer Center · Other
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About This Trial
This phase I trial studies how well zirconium (Zr)-89 crefmirlimab berdoxam and immuno-positron emission tomography (PET) identifies areas of immune cell activity in patients with brain tumors that can be removed by surgery (resectable). One important predictor of the immune response is the presence and change in CD8 positive (+) tumor infiltrating lymphocytes (TIL) cells. Identifying the presence…
Trial Locations
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Eligibility Criteria
Inclusion Criteria: * Male or female \>= 18 years of age * Documentation of a diagnosis of brain tumor including brain metastases, any grade of gliomas and meningiomas * The participant is scheduled for standard of care surgical tumor resection * The participant (or legally acceptable representativ…
Contacts

Sichen Li

310-592-9091

sichenli@mednet.ucla.edu

CONTACT