The Effectiveness of Heat Treatment on Knee Pain in Patients With Osteoarthritis - an International, Multicenter Clinical Investigation

Inclusion Criteria: * Signed written informed consent before inclusion in the investigation. * Any gender, any ethnic origin, 19-69 years old inclusive. * Body Mass Index 18.5-40 kg/m2 inclusive. * Full comprehension: ability to comprehend the full nature and purpose of the clinical investigation. * Patient with diagnosis of mono or bilateral moderate knee osteoarthritis with knee pain intensity \> 40 mm on a 0-100 mm VAS, able to independently ambulate without walking aid. * Availability of a radiography of the selected knee not older than 6 months. * Patient is either not of childbearing potential or must agree not to start a pregnancy from the signature of the informed consent up to the final visit Exclusion Criteria: * Clinically significant abnormal physical findings which could interfere with the objectives of the investigation * History of anaphylaxis to drugs or allergic reactions in general, which could affect the outcome of the clinical investigation. * Significant history of diseases that may interfere with the aim of the clinical investigation. * History of (in the last 6 months) or ongoing intra-articular injection involving the selected knee. History of ongoing physical therapy involving the selected knee. * Presence of flares, inflammation, effusion and swelling at the selected knee. * Any skin injury, wound, irritation, rash, bump, sore and/or discoloration at the application area. * Surgery at the selected knee in the 12 months preceding the clinical investigation. * Any medication that could interfere with the investigation procedures or investigation outcome. * Use of other hot or cold therapies for the selected knee. * Positive pregnancy test at screening; pregnant or breastfeeding women * History of (within the past 12 months) or current drugs or alcohol abuse * Individuals unable to fully understand all aspects of the investigation that are relevant to the decision to participate, or who could be manipulated or unduly influenced because of a compromised position, expectation of benefits or fear of retaliatory response.