No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
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Review the details below, then apply to join this clinical trial.
At a Glance
Age
18 and older
Sex
Any
Trial phase
Early Phase 1
Study type
Interventional
Purpose
Other
Participants needed
56 (estimated)
Sponsor
Shirley Ryan AbilityLab · Other
Who this trial is looking for
This trial is looking for people aged 18 or older who have had a stroke at least 8 months ago or who are healthy without a history of stroke. Participants will take part in movement training to see its effects on recovery.
Are You a Good Fit for This Trial?
You may be able to join if
I am 18 years old or older
I have had a stroke for at least 8 months or I am a healthy participant
I can provide informed consent
I have some movement capability in my shoulder and elbow
You may not be able to join if
I have severe medical problems that affect my health
I have visual problems that would affect my ability to participate
I have cognitive issues that might prevent me from taking part
I have severe weakness in my affected arm
I have had a Botox injection in my affected arm in the last 4 months
I have problems with blood pressure or blood oxygen levels
I have had multiple strokes or have severe brain injuries
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer a few quick questions to see if you may meet the eligibility requirements.
To determine the effects of 3D isometric movement training in healthy participants and impaired participants due to a stroke.
Trial Locations
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Eligibility Criteria
Inclusion criteria, neurotypical participants
* 18 years old
No history of stroke
Ability to provide informed consent .
Exclusion criteria, neurotypical participants
Severe medical problems (including cardiovascular, orthopedic, or neurological)
Medical problems affecting movement, range of mo…
Inclusion criteria, neurotypical participants
* 18 years old
No history of stroke
Ability to provide informed consent .
Exclusion criteria, neurotypical participants
Severe medical problems (including cardiovascular, orthopedic, or neurological)
Medical problems affecting movement, range of motion, strength, or coordination of the upper extremities.
Visual deficits that would influence the ability to perform the experiment . This will be assessed using the following assessments:
1. Visual field deficits will be assessed using the BIVABA acuity testing. (cutoff score \> 20/100)
2. Depth perception deficits will be assessed using the Stereofly test (require at least an angle of stereopsis at 16 inches is 3,552 seconds of arc).
4\) Blood pressure above 140 systolic and/or 90 diastolic mmHG
5\) Blood oxygen reading of less than 92% by finger pulse oximeter testing.
Inclusion Criteria , Stroke participants
* 18 years old
Chronic stroke (8+ months post)
Available medical records and radiographic information about lesion locations
Hemiparesis
Primary motor cortex involvement
Some degree of both shoulder and elbow movement capability
Exclusion Criteria , Stroke participants
Bilateral paresis
Aphasia, cognitive impairment, or affective dysfunction that would influence the ability to perform the experiment, This will be assessed using the Mini Mental State Examination31, with cut-off scores (adjusted for education level) as follows:
Participants whose education are 7th grade or lower, a score 22 or lower
Participants whose education attainment level is 8th grade or some high school (but not a graduate), a score of 24 or lower
Participants whose education attainment level is high school graduate, a score of 25 or lower
Participants whose education attainment level is some college or higher, a score 26 or lower
Visual deficits, and hemispatial neglect that would prevent the participants from seeing the targets. A vision test will be done if the participant indicates in their screen that their stroke has affected their vision. This will be tested using the following assessments:
Visual field loss will be assessed using the BIVABA acuity test10. (cutoff score \> 20/100)
Visual Extinction and Inattention using Star Cancellation Test9. (cutoff score of \<44)
Depth perception deficits will be assessed using the Stereofly test (require at least an angle of stereopsis at 16 inches is 3,552 seconds of arc).
Modified Ashworth score of 4 at shoulder or elbow joints.
Rated below 15 on the FMUE scale
Inability to provide an informed consent
severe current medical problems
Severe sensory deficit in the affected limb (Cannot be absent in any part of affected UE)
diffuse/multiple lesion sites or multiple stroke events
Inability to attain and maintain testing positions
Botox or other botulinum toxin injection to the affected upper extremity within the previous 4 months
Concurrent participation in upper extremity rehabilitation either as part of a research intervention protocol or a prescribed therapy
Neurological, neuromuscular, or orthopedic diseases (i.e. injuries to your affected arm or hand)
Other neurological issues (Parkinson's, CP)
Blood Pressure above 140 systolic and/or 90 diastolic mmHg
Blood oxygen reading of less than 92% on finger pulse oximetry testing.
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