Prognostic Biomarkers for Selective Intra-Arterial Cooling Infusion Combined with Endovascular Thrombectomy in Acute Ischemic Stroke Based on Proteomics and Metabolomics.

Inclusion Criteria: * Age ≥18 and ≤80. * Clinical signs consistent with acute ischemic stroke with large vessel occlusion in the anterior circulation (intracranial segment of the internal carotid artery, middle cerebral artery M1 segment) demonstrated with CTA/MRA/DSA. * NIHSS score obtained prior to randomization ≥6 and ≤25. * Modified Rankin Scale ≤ 1 prior to qualifying stroke. * Arterial puncture performed within 24 hours from symptom onset or LKW. * For the patients with symptom onset within 6 hours, the ASPECT score ≥6; for the patientswith onset within 6-24 hours, the therapy should meet the imaging criteria of DAWN or DEFUSE-3 trial. * Patient/Legally Authorized Representative has signed the Informed Consent Form. Exclusion Criteria: * Baseline CT/MRI confirms the presence of multiple vascular territory acute strokes. * Baseline CT/MRI confirms the presence of arterial dissection. * Evidence of intracranial hemorrhage or hemorrhagic transformation before thrombectomy. * Known allergies or intolerances to antiplatelet agents, anticoagulation drugs, iodinated contrast and/or anesthetics. * Severe infection (e.g. sepsis) or multiple organ failure. * Known hereditary or acquired hemorrhagic diathesis, coagulation factor deficiency; recent oral anticoagulant therapy with INR \> 3. Patients on factor Xa inhibitor for 48 hours ago must have a normal APTT. * Baseline platelet count \<50 × 109/L. * Blood glucose concentration\<50 mg/dL (2.7mmol/L) or \>400 mg/dL (22.2mmol/L). * Refractory hypertension that is difficult to control by medication (Defined as persistent systolic blood pressure\>185 mmHg or diastolic blood pressure\>110mmHg). * Previous NHYA\>1. * Untreated moderate or severe coronary artery stenosis, or previous coronary artery bypass surgery. * Undergoing hemodialysis or peritoneal dialysis; known severe renal insufficiency with glomerular filtration rate \<30 ml/min or serum creatinine \>220 mmol/L (2.5mg/dl). * Known intracranial aneurysm, and cerebral arteriovenous malformation. * Malignant brain tumor or CNS infection. * Pre-existing neurological or psychiatric disease that would confound the neurological or functional evaluations (e.g., dementia or mental illness) * Female who is pregnant or lactating at time of admission. * Anticipated life expectancy \<6 months. * Current participation in another investigational drug or device study. * For other reasons, the responsible clinicians believe that the patient is not suitable for continued treatment.