Screening for Islet Autoantibodies in Family Members of T1D Patients
A National Screening Program for Islet Autoantibodies Among First-degree Relatives of T1D Patients
Recruiting
Observational Study
Type 1 DiabetesAutoantibodies Screening
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
2 – 45
Sex
Any
Study type
Observational
Participants needed
20,000 (estimated)
Sponsor
Rabin Medical Center · Other
Who this trial is looking for
This trial is looking for family members of people with type 1 diabetes to check for certain autoantibodies. If found, participants will receive education to help prevent further diabetes-related issues.
Are You a Good Fit for This Trial?
You may be able to join if
I am between 2 and 45 years old.
I am a first-degree relative of someone with type 1 diabetes.
I can sign an informed consent.
You may not be able to join if
I have known diabetes of any kind.
I have been treated with insulin or oral diabetes medications.
I am currently using systemic immunosuppressive agents.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer a few quick questions to see if you may meet the eligibility requirements.
A national Screening program for the presence of Islet Autoantibodies (IA) in relatives of people with type 1 diabetes (PWT1D) aiming at identifying people with pre-clinical (stage 1 \& 2) T1D and DKA prevention on the clinical presentation of T1D. All participants will be screened at study entry for the presence of 4 islet autoantibodies: glutamic acid decarboxylase antibody (GADA), insulinoma-as…
A national Screening program for the presence of Islet Autoantibodies (IA) in relatives of people with type 1 diabetes (PWT1D) aiming at identifying people with pre-clinical (stage 1 \& 2) T1D and DKA prevention on the clinical presentation of T1D. All participants will be screened at study entry for the presence of 4 islet autoantibodies: glutamic acid decarboxylase antibody (GADA), insulinoma-associated-2 antibody (IA-2A), insulin antibodies (IAA) and Zinc transporter-8 antibodies (ZnT8A). The ADAP assay will be used to detect IA.
A confirmation blood sample for positive participants with two or more IA will be taken. The confirmation analysis will be done by the ADAP assay, conventional ELISA, and RIA.
Participants identified as part of the study with pre-symptomatic type 1 diabetes (T1D) (stages 1 and 2) will be referred to complete an educational program emphasizing DKA prevention as part of routine medical care .During the study, cases of stage 2 and stage 3 diabetes and DKA events in participants who are positive for IA will be documented.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Age 2-45 years
* First-degree relatives of Type 1 Diabetes probands
* Signing an informed consent
Exclusion Criteria:
* Known diabetes of any kind (type 1, type 2, MODY)
* Have a previous history of being treated with insulin or oral diabetes medications.
* Currently, using …
Inclusion Criteria:
* Age 2-45 years
* First-degree relatives of Type 1 Diabetes probands
* Signing an informed consent
Exclusion Criteria:
* Known diabetes of any kind (type 1, type 2, MODY)
* Have a previous history of being treated with insulin or oral diabetes medications.
* Currently, using systemic immunosuppressive agents (topical and inhaled agents are acceptable)
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