ECMO is widely used in patients with refractory respiratory and/or circulatory failure.The data shows that the incidence of bleeding and thrombotic events is still above 40%,and it is closely related to the increase in mortality rate.Therefore, optimizing ECMO anticoagulation management to reduce bleeding and thrombotic events is a key scientific issue that urgently needs to be addressed.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* age older than 18 years old
* received ECMO because of severe respiratory failure
Exclusion Criteria:
* anticoagulant contraindications
* cerebral infarction or suspected patients
* severe hypertension
* women in gestational and lactational period
* hemophilia
* allergic to …
Inclusion Criteria:
* age older than 18 years old
* received ECMO because of severe respiratory failure
Exclusion Criteria:
* anticoagulant contraindications
* cerebral infarction or suspected patients
* severe hypertension
* women in gestational and lactational period
* hemophilia
* allergic to heparin or Nafamostat
* unwilling or unable to complete the study
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