Lower Platelet Transfusion Threshold for Premature Infants

Neonatal Platelet Transfusion Threshold Trial

Recruiting N/A Interventional Study
Thrombocytopenia Neonatal Platelet Transfusion Infant, Newborn, Diseases Infant, Extremely Low Birth Weight Infant, Small for Gestational Age Thrombosis
No Placebo Group Every participant receives an active treatment — no one gets a placebo. Healthy Volunteers Welcome You do not need to have the condition being studied to take part.
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Review the details below, then apply to join this clinical trial.

At a Glance
Age
1 Hour – 48 Hours
Sex
Any
Study type
Interventional
Purpose
Prevention
Participants needed
2,433 (estimated)
Sponsor
NICHD Neonatal Research Network · Research network
Who this trial is looking for

This trial is looking for extremely preterm infants born between 23 to 27 weeks of gestation. It aims to find out if using a lower amount of platelet transfusion helps improve survival without major bleeding.

Are You a Good Fit for This Trial?

You may be able to join if

  • I was born between 23 and 27 weeks of gestation
  • I am less than 48 hours old

You may not be able to join if

  • I am receiving comfort care or my care is being withdrawn
  • I have a bleeding disorder or thrombocytopenia
  • I have already received a platelet transfusion
  • I have not received Vitamin K
  • My parents or guardian do not agree to my participation

Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.

Think this trial could be right for you?

Answer a few quick questions to see if you may meet the eligibility requirements.

Check Your Eligibility
About This Trial

The objective of the NeoPlaTT trial is to test whether, among extremely preterm infants born at 23 0/7 to 26 6/7 weeks' gestation, a lower platelet transfusion threshold, compared to a higher threshold, improves survival without major or severe bleeding up to 40 0/7 weeks' postmenstrual age (PMA).

Trial Locations
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Eligibility Criteria
Inclusion Criteria: * Gestational age of 23 0/7 to 26 6/7 weeks * Postnatal age of \< 48 hours Exclusion Criteria: * Comfort care or withdrawal of care planned * Neonatal alloimmune thrombocytopenia or suspected/confirmed congenital platelet or bleeding disorder * Receipt of platelet transfusion …
Contacts

Ravi M Patel, MD

404-727-5905

rmpatel@emory.edu

CONTACT

Abhik Das, PhD

301-230-4640

adas@rti.org

CONTACT