No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
21 – 90
Sex
Any
Study type
Interventional
Purpose
Treatment
Participants needed
108 (estimated)
Sponsor
The University of Texas Medical Branch, Galveston · Other
Who this trial is looking for
This trial is looking for people aged 21 to 90 who have had a stroke at least 6 months ago. Participants will take part in activities that help improve their leg skills through brain stimulation.
Are You a Good Fit for This Trial?
You may be able to join if
I am between 21 and 90 years old.
I have had a stroke at least 6 months ago.
I have weakness in one leg.
I can walk independently for 10 meters.
I can stand without help for more than 30 seconds.
I can see clearly with glasses or contacts.
I have a Mini-Mental Status Exam score of 24 or higher.
You may not be able to join if
I am currently pregnant.
I have lesions in my brain or tumors.
I have metal implants or a cardiac pacemaker.
I have a history of seizures.
I have disorders that limit my ability to exercise.
I have major cognitive problems.
I have unstable angina.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
This research study aims to understand the relationship between brain stimulation and leg skill learning in both healthy adults and persons with chronic stroke.
Trial Locations
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City
State
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Status
Eligibility Criteria
Inclusion Criteria:
1. Age between 21 and 90 years
2. Medical history of a unilateral stroke occurring ≥ 6 months prior to enrollment
3. MRI or CT evidence from the imaging report shown that the stroke involves the corticospinal tract
4. Hemiparesis involving the lower extremity (Fulg-Meyer LE moto…
Inclusion Criteria:
1. Age between 21 and 90 years
2. Medical history of a unilateral stroke occurring ≥ 6 months prior to enrollment
3. MRI or CT evidence from the imaging report shown that the stroke involves the corticospinal tract
4. Hemiparesis involving the lower extremity (Fulg-Meyer LE motor test)
5. No passive range of motion limitation in bilateral hips and knees
6. Limitation of ankle passive range of motion to 10 degrees of dorsiflexion or less
7. Visual acuity can be corrected by glasses or contact lens to 20/20
8. Able to walk independently with/without assistant devices for 10 meters
9. Able to maintain standing position without any assistance \> 30 sec (Short Physical Performance Battery)
10. Evaluation of cognitive status: Mini-mental status examination (MMSE) score ≥ 24
Exclusion Criteria:
1. Pregnant women
2. MRI or CT evidence of involvement of the basal ganglia or cerebellum, evidence of multiple lesions, or evidence of any other brain damage or malignant neoplasm or tumors
3. Have any metal implants, cardiac pacemakers, or history of seizures
4. Ongoing orthopedic or other neuromuscular disorders that will restrict exercise training
5. Any vestibular dysfunction or unstable angina
6. Significant cognitive deficits (inability to follow a 2-step command) or severe receptive or global aphasia\*
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