Diet Impact on Muscle Building for Healthy Young Males
The Importance of Non-essential Amino Acids for Maintaining Skeletal Muscle Protein Synthesis Rates in Healthy Young Men
Recruiting
N/AInterventional Study
Healthy Males
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
18 – 35
Sex
Male
Study type
Interventional
Purpose
Basic Science
Participants needed
64 (estimated)
Sponsor
Maastricht University Medical Center · Other
Who this trial is looking for
This trial is looking for healthy young men aged 18 to 35. Participants will follow a special diet for 10 days to see how it affects muscle growth and metabolism.
Are You a Good Fit for This Trial?
Must not be takingCorticosteroidsNon-steroidal anti-inflammatoriesGastric acid suppressing medicationsAnti-coagulants
Rules you outCardiovascular diseaseHypertension
You may be able to join if
I am male
I am between 18 and 35 years old
My BMI is between 22 and 30
I do not smoke
I can give my informed consent
You may not be able to join if
I participate in a structured exercise program
I smoke
I have digestive tract disorders
I have musculoskeletal disorders
I have metabolic disorders like diabetes
I have heart disease
I have high blood pressure
I have any intolerance to the foods in the study diet
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer a few quick questions to see if you may meet the eligibility requirements.
Background: Protein intake is important for maintaining skeletal muscle mass. These proteins consist of a collection of small building blocks which are called amino acids. There are two types of amino acids that are needed to build muscle: essential amino acids (EAA) and non-essential amino acids (NEAA). EAAs cannot be made in the body and must be consumed through foods, while NEAAs can be made wi…
Background: Protein intake is important for maintaining skeletal muscle mass. These proteins consist of a collection of small building blocks which are called amino acids. There are two types of amino acids that are needed to build muscle: essential amino acids (EAA) and non-essential amino acids (NEAA). EAAs cannot be made in the body and must be consumed through foods, while NEAAs can be made within the body. However, if NEAA are not consumed through foods, the process of making NEAA in the body costs the body energy. It is still unknown what the impact of a diet containing too few non-essential amino acids is for muscle building and the body's energy metabolism.
Objective: To determine if a diet lacking NEAA, with or without being replaced by additional EAA, influences muscle protein building and whole-body metabolism.
Study design: Randomized, parallel design, double-blind, 10-day dietary intervention study.
Study population: 45 healthy (BMI 22-30 kg/m2) young males (age: 18-35 y inclusive).
Hypothesis: It is hypothesized that a diet lacking NEAA, with or without being replaced by additional EAA, decreases muscle protein building in humans.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Male
* Age between 18 and 35 y inclusive
* BMI between 22 and 30 kg/m2
* Non-smoker
* Having given informed consent
Exclusion Criteria:
* Participating in a structured (progressive) exercise program
* Smoker
* Diagnosed GI tract disorders or diseases
* Diagnosed musculoskele…
Inclusion Criteria:
* Male
* Age between 18 and 35 y inclusive
* BMI between 22 and 30 kg/m2
* Non-smoker
* Having given informed consent
Exclusion Criteria:
* Participating in a structured (progressive) exercise program
* Smoker
* Diagnosed GI tract disorders or diseases
* Diagnosed musculoskeletal disorders
* Diagnosed metabolic disorders (e.g. diabetes)
* Cardiovascular disease
* Hypertension (blood pressure above 140/90 mmHg)
* Donated blood 3 months prior to test day
* Use of any medications known to affect protein metabolism (i.e. corticosteroids, non-steroidal anti-inflammatories).
* Chronic use of gastric acid suppressing medication
* Chronic use of anti-coagulants
* Any intolerance to foods included in the standardized diet intervention
* Any implants that would be a contra-indication for performing an MRI scan
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