The Association of Psychological Stress with the Efficacy of Neoadjuvant Therapy in Breast Cancer

Inclusion Criteria: * 1.Age ≥ 18 years; 2.Histological and/or cytological diagnosis of breast cancer; 3.Treatment niave patients; 4.To receive standard neoadjuvant therapy; 5.Eastern Cooperative Oncology Group (ECOG) performance status of 0-1; 6.Presence of at least one measurable lesion according to the Response Evaluation Criteria in Advanced Solid Tumors version 1.1 (RECIST v1.1) ; 7.Informed and agreed to participate in the study; Exclusion Criteria: * 1\. Breast cancer has not been confirmed through histological or cytological examinations. 2.Other breast cancer conditions that do not receive neoadjuvant therapy. 3.Combined with other malignant tumors. 4.Concurrent acute or chronic psychiatric disorders, along with having received antidepressant or anti-anxiety therapy within the past month. 5.Participants must not have engaged in any other clinical trials in the past month, unless those trials are observational or non-interventional in nature.