Efficacy and Influencing Factors of Deep Transcranial Magnetic Stimulation in the Treatment of OCD
Recruiting
N/AInterventional Study
Obsessive-Compulsive Disorder
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
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Review the details below, then apply to join this clinical trial.
At a Glance
Age
18 – 50
Sex
Any
Study type
Interventional
Purpose
Treatment
Participants needed
70 (estimated)
Sponsor
Zhen Wang · Other
Who this trial is looking for
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This study aims to explore the efficacy and influencing of accelerated dTMS (deep Transcranial Magnetic Stimulation) treatment in patients with obsessive-compulsive disorder (OCD), and explores the potential neural mechanisms of treatment effect by magnetic resonance imaging (MRI) and electroencephalography (EEG).
Trial Locations
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Status
Eligibility Criteria
Inclusion Criteria:
* Aged between 18 and 50, both genders are welcome.
* DSM-5 criteria for OCD.
* Y-BOCS total score ≥ 20 despite therapeutic-dose SRI treatment or completion of at least one full course of CBT. The treatment regimen must have been stable for at least 8 weeks prior to enrollment a…
Inclusion Criteria:
* Aged between 18 and 50, both genders are welcome.
* DSM-5 criteria for OCD.
* Y-BOCS total score ≥ 20 despite therapeutic-dose SRI treatment or completion of at least one full course of CBT. The treatment regimen must have been stable for at least 8 weeks prior to enrollment and remain unchanged throughout the study.
* More than 9 years of education.
* Right-handed.
Exclusion Criteria:
* Any additional current psychiatric comorbidity, except for obsessive- compulsive personality disorder.
* Severe obsessive symptoms prevent the completion of necessary assessments.
* Has a history of receiving ECT therapy.
* Has received rTMS or tDCS treatment within the past two months.
* Has severe physical illnesses or any physical conditions that can induce epilepsy or intracranial hypertension, including cardiovascular and respiratory diseases, among others.
* Has a past history of neurological disorders (such as epilepsy, cerebrovascular accidents, etc.) or brain injuries, or a history of brain surgery.
* Has implanted medical devices such as intracranial stents, cardiac pacemakers, coronary stents, cochlear implants, etc.
* Serious suicide risk.
* Pregnancy or nursing of an infant.
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