Psilocybin and Midazolam for Emotional Wellbeing
The RECAP2 Study: Midazolam and Psilocybin
Recruiting
Phase 1
Interventional Study
Psilocybin
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
At a Glance
- Age
- 18 – 65
- Sex
- Any
- Trial phase
- Phase 1
- Study type
- Interventional
- Purpose
- Basic Science
- Participants needed
- 60 (estimated)
- Sponsor
- University of Wisconsin, Madison · Other
Who this trial is looking for
This trial is looking for adults aged 18 to 65 who have experienced a mild decline in emotional wellbeing. Participants will receive one of four medication combinations and undergo some brain scans and tests.
Are You a Good Fit for This Trial?
You may be able to join if
- I am between 18 and 65 years old.
- I am physically healthy.
- I speak English.
- I have a modest decrease in my wellbeing without a major mood or anxiety disorder.
- I can undergo an MRI and TMS.
You may not be able to join if
- I have a psychiatric diagnosis that excludes me.
- I have active suicidal thoughts.
- I have significant medical conditions.
- I have serious lab test results.
- I have a significant ECG issue.
- I have taken psychiatric or CNS-altering medications in the last 3 months.
- I have hypertension or tachycardia.
Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.
Think this trial could be right for you?
Answer a few quick questions to see if you may meet the eligibility requirements.
Check Your Eligibility
About This Trial
The goal of this clinical trial is to learn about the role that inducing neuroplasticity (the brain's ability to adapt and change) plays in the behavioral effects of psilocybin in people who have experienced a mild decline in emotional wellbeing.
Researchers will compare different doses of psilocybin combined with midazolam or placebo to see what dose induces increased wellbeing.
Participants wi…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Age 18 to 65 years at screening, of any identified gender and racial/ethnic group
* Physically healthy; does not meet criteria for an exclusionary medical condition
* English-speaking (able to provide consent and complete questionnaires)
* Modest decrement in self-reported wel…
Contacts